ArticleJournal of veterinary internal medicine2026
Clinical presentation, prognostic factors, and outcomes of meningoencephalitis of unknown origin in older dogs.
Article in Journal of veterinary internal medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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4 authors.
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Abstract
backgroundThe clinical presentation and outcomes of older dogs with meningoencephalitis of unknown origin (MUO) have not been described previously. HYPOTHESIS/
objectivesCompare clinical presentations and outcomes of an older cohort (≥8 years old) of dogs diagnosed with MUO compared to a younger cohort. ANIMALS: Client-owned dogs diagnosed with MUO including 71 dogs ≥ 8 years old and 142 control dogs < 8 years old.
methodsMulticenter retrospective case-control study. Data were collected from the clinical records of 2 referral centers and referring veterinarians were contacted for additional survival data. Survival and relapse rates of the older and younger cohorts were compared.
resultsOn presentation, older dogs were found to be significantly more likely to have behavior changes (P = .01), cranial nerve deficits (P < .001), and comorbidities (P < .001) compared with younger dogs. On multivariate analysis, median survival time between the 2 groups did not differ significantly (16 months for older dogs and 24 months for younger dogs, P = .48). No significant difference was found in relapse rates between the 2 groups: 67/103 (65.0%) younger dogs and 20/48 (41.7%) older dogs relapsed within the study period. CONCLUSIONS AND CLINICAL IMPORTANCE: Older dogs with MUO were found to have similar survival times and relapse rates compared to younger dogs with MUO.
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