ArticlemBio2026
SspE-mediated immune defense: GTP hydrolysis as an allosteric switch coupling phosphorothioate recognition to DNA cleavage.
Yufeng Zhou, Kuo Zhang, Yu He, Haiyan Gao, Yuhang Zhong, Xiaoguang Wang, Meiying Wang, Lianrong Wang, Shi Chen
Abstract read
In one paragraphArticle in mBio, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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2 · The registryThe trial behind it
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5 · Who and what moneyAuthors and funding
9 authors.
Yufeng Zhou *Department of Gastroenterology, Ministry of Education Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, Hubei Clinical Center and Key Laboratory of Intestinal and Colorectal Disease, Zhongnan Hospital of Wuhan University, School of Pharmaceutical Sciences, Wuhan University, Wuhan, Hubei, China.ORCID 0009-0003-5324-5191 Kuo Zhang *Department of Respiratory Diseases, Institute of Pediatrics, Shenzhen University Medical School, Shenzhen Children's Hospital, Shenzhen, China.
Yu HeDepartment of Respiratory Diseases, Institute of Pediatrics, Shenzhen University Medical School, Shenzhen Children's Hospital, Shenzhen, China.
Haiyan GaoDepartment of Gastroenterology, Ministry of Education Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, Hubei Clinical Center and Key Laboratory of Intestinal and Colorectal Disease, Zhongnan Hospital of Wuhan University, School of Pharmaceutical Sciences, Wuhan University, Wuhan, Hubei, China.
Yuhang ZhongDepartment of Gastroenterology, Ministry of Education Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, Hubei Clinical Center and Key Laboratory of Intestinal and Colorectal Disease, Zhongnan Hospital of Wuhan University, School of Pharmaceutical Sciences, Wuhan University, Wuhan, Hubei, China.
Xiaoguang WangDepartment of Surgery, Affiliated Hospital of Jiaxing University, Jiaxing, Zhejiang, China.
Meiying WangDepartment of Rheumatology and Immunology, Shenzhen Key Laboratory of Microbiology in Genomic Modification & Editing and Application, Shenzhen Institute of Translational Medicine, Shenzhen University Medical School, The First Affiliated Hospital of Shenzhen University, Shenzhen, China.ORCID 0000-0003-3563-9974 Lianrong WangDepartment of Respiratory Diseases, Institute of Pediatrics, Shenzhen University Medical School, Shenzhen Children's Hospital, Shenzhen, China.ORCID 0000-0003-1669-6340 Shi ChenDepartment of Gastroenterology, Ministry of Education Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, Hubei Clinical Center and Key Laboratory of Intestinal and Colorectal Disease, Zhongnan Hospital of Wuhan University, School of Pharmaceutical Sciences, Wuhan University, Wuhan, Hubei, China.ORCID 0000-0002-8965-1015 Funding
No grant is acknowledged in the PubMed record.
6 · The paper itselfAbstract
DNA phosphorothioate (PT) modification is an epigenetic mark that enables bacteria to discriminate self from non-self DNA, directing restriction effectors to cleave unmodified foreign DNA. In the PT-dependent Ssp system, SspE acts as the restriction effector that recognizes PT marks to block phage propagation. While the mechanism of the Streptomyces homolog (StSspE) is known, the basis for the exceptional potency of
Indexed as
Bacterial ProteinsDNA CleavageEscherichia coliEscherichia coli ProteinsGuanosine TriphosphatePhosphatesAllosteric RegulationCryoelectron MicroscopyHydrolysisPhosphorothioate OligonucleotidesBacterial ProteinsEscherichia coli ProteinsGuanosine TriphosphatePhosphatesPhosphorothioate Oligonucleotidesallosteric regulationanti-phage defenseDNA phosphorothioation
Identifiers
PMID42117685
PMCPMC13251355
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