Evidence map›Paper›PMID 42117627›Full record

ArticleAutophagy2026

Intracellular lipopolysaccharide binds RETREG1/FAM134B to regulate ER remodeling upon bacterial infection.

Yi-Lin Cheng, João Mello-Vieira, Adriana Covarrubias-Pinto, Alexis Gonzalez, Santosh Kumar Kuncha, Chun Kew, Kaiyi Zhang, Muhammad Awais Afzal, Nour Diab, Sophia Borchert and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Autophagy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Yi-Lin ChengInstitute of Biochemistry II, Faculty of Medicine, Goethe University, Frankfurt, Germany.ORCID 0000-0002-3603-5913
João Mello-VieiraInstitute of Biochemistry II, Faculty of Medicine, Goethe University, Frankfurt, Germany.ORCID 0000-0003-1665-4781
Adriana Covarrubias-PintoInstitute of Biochemistry II, Faculty of Medicine, Goethe University, Frankfurt, Germany.ORCID 0000-0002-8946-2804
Alexis GonzalezInstitute of Biochemistry II, Faculty of Medicine, Goethe University, Frankfurt, Germany.ORCID 0000-0003-3741-6854
Santosh Kumar KunchaInstitute of Biochemistry II, Faculty of Medicine, Goethe University, Frankfurt, Germany.ORCID 0000-0002-2538-8342
Chun KewInstitute of Biochemistry II, Faculty of Medicine, Goethe University, Frankfurt, Germany.
Kaiyi ZhangInstitute of Medical Microbiology, RWTH University Hospital, Aachen, Germany.
Muhammad Awais AfzalInstitute of Human Genetics, Jena University Hospital, Friedrich Schiller University, Jena, Germany.
Nour DiabInstitute of Medical Microbiology, RWTH University Hospital, Aachen, Germany.
Sophia BorchertAbt. Mikrobiologie, Universität Osnabrück, Osnabrück, Germany.
Siou-Ying HongInstitute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Timothy Chun HuangInstitute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Wenbo ChenInstitute of Biochemistry II, Faculty of Medicine, Goethe University, Frankfurt, Germany.
Uxía Gestal MatoInstitute of Biochemistry II, Faculty of Medicine, Goethe University, Frankfurt, Germany.
Mathias Walter HornefInstitute of Medical Microbiology, RWTH University Hospital, Aachen, Germany.
Christian A HübnerInstitute of Human Genetics, Jena University Hospital, Friedrich Schiller University, Jena, Germany.
Michael HenselAbt. Mikrobiologie, Universität Osnabrück, Osnabrück, Germany.ORCID 0000-0001-6604-6253
Ivan DikicInstitute of Biochemistry II, Faculty of Medicine, Goethe University, Frankfurt, Germany.ORCID 0000-0001-8156-9511

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Selective autophagy of the endoplasmic reticulum (ER), termed ERphagy or reticulophagy, plays a key role in organelle remodeling and cellular homeostasis. However, whether and how ERphagy is regulated during Gram-negative bacteria infection to influence host responses remains unclear. Here, we show that

Indexed as

AutophagyEndoplasmic ReticulumLipopolysaccharidesMembrane ProteinsAnimalsHumansProtein BindingSalmonella typhimuriumLipopolysaccharidesMembrane ProteinsER remodelinglipopolysaccharideouter membrane vesiclesRETREG1Salmonellaxenophagy

Identifiers

PMID42117627
PMCPMC13501995

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.