Evidence map›Paper›PMID 42117622›Full record

ArticleJournal of enzyme inhibition and medicinal chemistry2026

Cadmium inhibits hSMUG1-mediated uracil excision: quantitative analysis and mitigation by

Hui-Lan Chang, Cheng-Hao Fang, Hsing-Lin Chang, Ya-Fen Lee, Wei-Lun Hsu, Jung-Hsuan Chang, Min-Hui Chien, Steven D Goodman, Sui-Yuan Chang, Woei-Horng Fang and 1 more

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In one paragraph

Article in Journal of enzyme inhibition and medicinal chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Hui-Lan ChangDepartment of Clinical Laboratory Sciences and Medical Biotechnology, College of Medicine, National Taiwan University, Taipei, Taiwan, ROC.
Cheng-Hao FangDepartment of Clinical Laboratory Sciences and Medical Biotechnology, College of Medicine, National Taiwan University, Taipei, Taiwan, ROC.
Hsing-Lin ChangDepartment of Clinical Laboratory Sciences and Medical Biotechnology, College of Medicine, National Taiwan University, Taipei, Taiwan, ROC.
Ya-Fen LeeDepartment of Laboratory Medicine, National Taiwan University Hospital, Taipei, Taiwan, ROC.
Wei-Lun HsuDepartment of Clinical Laboratory Sciences and Medical Biotechnology, College of Medicine, National Taiwan University, Taipei, Taiwan, ROC.
Jung-Hsuan ChangDepartment of Clinical Laboratory Sciences and Medical Biotechnology, College of Medicine, National Taiwan University, Taipei, Taiwan, ROC.
Min-Hui ChienDepartment of Clinical Laboratory Sciences and Medical Biotechnology, College of Medicine, National Taiwan University, Taipei, Taiwan, ROC.
Steven D GoodmanCenter for Microbial Pathogenesis, Nationwide Children's Hospital and the Department of Pediatrics, Ohio State University, Columbus, OH, USA.
Sui-Yuan ChangDepartment of Clinical Laboratory Sciences and Medical Biotechnology, College of Medicine, National Taiwan University, Taipei, Taiwan, ROC.
Woei-Horng FangDepartment of Clinical Laboratory Sciences and Medical Biotechnology, College of Medicine, National Taiwan University, Taipei, Taiwan, ROC.
Kang-Yi SuDepartment of Clinical Laboratory Sciences and Medical Biotechnology, College of Medicine, National Taiwan University, Taipei, Taiwan, ROC.ORCID 0000-0002-6538-9526

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cadmium is a pervasive environmental carcinogen known to disrupt multiple DNA repair pathways, yet its direct impact on uracil base excision repair enzyme activity remains unclear. Here, we quantitatively demonstrate that cadmium potently inhibits hSMUG1, a key enzyme initiating removal of mutagenic U:G mispairs arising from cytosine deamination. Using a nucleotide-resolution MALDI-TOF mass spectrometry assay, we show that cadmium suppresses hSMUG1 activity in a dose-dependent manner (IC

Indexed as

CadmiumEnzyme InhibitorsReishiUracilUracil-DNA GlycosidaseDNA RepairDose-Response Relationship, DrugExcision RepairHumansMolecular StructureStructure-Activity RelationshipCadmiumEnzyme InhibitorsSMUG1 protein, humanUracilUracil-DNA GlycosidaseCadmiumDNA repairGanodermahSMUG1uracil excision

Identifiers

PMID42117622
PMCPMC13169448

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.