Evidence map›Paper›PMID 42117381›Full record

ArticleAnalytical chemistry2026

Analyses of Individual Singly Charged Ions Using a High-Field Orbitrap Analyzer.

Elena Giaretta, Evolène Deslignière, Eduard H T M Ebberink, Tobias P Wörner, Arjan Barendregt, Kyle L Fort, Alexander A Makarov, Albert J R Heck

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Analytical chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Elena GiarettaBiomolecular Mass Spectrometry and Proteomics, Bijvoet Center for Biomolecular Research and Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht 3584 CH, The Netherlands.ORCID 0009-0001-2351-2581
Evolène DeslignièreBiomolecular Mass Spectrometry and Proteomics, Bijvoet Center for Biomolecular Research and Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht 3584 CH, The Netherlands.
Eduard H T M EbberinkBiomolecular Mass Spectrometry and Proteomics, Bijvoet Center for Biomolecular Research and Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht 3584 CH, The Netherlands.
Tobias P WörnerThermo Fisher Scientific GmbH, Bremen 28199, Germany.
Arjan BarendregtBiomolecular Mass Spectrometry and Proteomics, Bijvoet Center for Biomolecular Research and Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht 3584 CH, The Netherlands.
Kyle L FortBiomolecular Mass Spectrometry and Proteomics, Bijvoet Center for Biomolecular Research and Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht 3584 CH, The Netherlands.
Alexander A MakarovBiomolecular Mass Spectrometry and Proteomics, Bijvoet Center for Biomolecular Research and Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht 3584 CH, The Netherlands.ORCID 0000-0002-7046-6709
Albert J R HeckBiomolecular Mass Spectrometry and Proteomics, Bijvoet Center for Biomolecular Research and Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht 3584 CH, The Netherlands.ORCID 0000-0002-2405-4404

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Orbitrap-based charge detection mass spectrometry (CDMS) enables the mass analysis of biomolecules at the individual-ion level. Recording longer transients boosts resolution and sensitivity for CDMS measurements. However, singly charged analytes (∼1-2 kDa) remained elusive to Orbitrap-based CDMS due to their low signal-to-noise ratios (S/N). To overcome this limitation, we implemented CDMS on a high-field Orbitrap mass analyzer (HF-OT, Exploris 480 mass spectrometer) coupled to an external data acquisition system. The HF-OT analyzer should theoretically improve the resolution by 1.7-fold and the S/N by 1.4-fold compared to a standard Orbitrap analyzer (S-OT, UHMR mass spectrometer). We first adapted an Exploris 480 mass spectrometer to allow robust detection across an extended

Indexed as

Mass SpectrometryAnimalsAntibodies, MonoclonalBradykininInsulinIonsSerum Albumin, BovineSignal-To-Noise RatioAntibodies, MonoclonalBradykininInsulinIonsSerum Albumin, Bovine

Identifiers

PMID42117381
PMCPMC13218364

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.