Evidence map›Paper›PMID 42117234›Full record

SynthesisSpecial care in dentistry : official publication of the American Association of Hospital Dentists, the Academy of Dentistry for the Handicapped, and the American Society for Geriatric Dentistry

Mandibular Radiographic Assessment in Sickle Cell Disease: A Systematic Review of Radiomorphometric Indices and Fractal Dimension.

Diego Belmiro do Nascimento Santos, Bruna Cristina Oliveira Dos Santos, Larissa Conrado da Silva, Márcia Pereira Alves Dos Santos, Luciana Munhoz, Bruno Augusto Benevenuto de Andrade, Jefferson R Tenório

Abstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Special care in dentistry : official publication of the American Association of Hospital Dentists, the Academy of Dentistry for the Handicapped, and the American Society for Geriatric Dentistry. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Diego Belmiro do Nascimento SantosDepartment of Pathology and Oral Diagnosis, School of Dentistry, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Rio de Janeiro, Brazil.
Bruna Cristina Oliveira Dos SantosDepartment of Pathology and Oral Diagnosis, School of Dentistry, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Rio de Janeiro, Brazil.
Larissa Conrado da SilvaDepartment of Pathology and Oral Diagnosis, School of Dentistry, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Rio de Janeiro, Brazil.
Márcia Pereira Alves Dos SantosDepartment of Forensic Dentistry and Public Health, School of Dentistry, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Rio de Janeiro, Brazil.ORCID https://orcid.org/0000-0003-0349-8521
Luciana MunhozDepartment of Stomatology, School of Dentistry, Universidade de São Paulo, São Paulo, Brazil.ORCID https://orcid.org/0000-0003-2375-5935
Bruno Augusto Benevenuto de AndradeDepartment of Pathology and Oral Diagnosis, School of Dentistry, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Rio de Janeiro, Brazil.ORCID https://orcid.org/0000-0002-3259-606X
Jefferson R TenórioDepartment of Pathology and Oral Diagnosis, School of Dentistry, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Rio de Janeiro, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimThis systematic review aimed to investigate the association between sickle cell disease (SCD) and reduced bone mineral density (BMD) using radiomorphometric indices (RMI) and fractal dimension analysis (FDA) on dental radiographic images. METHODS AND

resultsObservational studies evaluating BMD in individuals with SCD through RMI or FDA were included. A comprehensive search was conducted across six databases and grey literature in March 2025. Risk of bias was evaluated using the Joanna Briggs Institute Critical Appraisal Tool for cross-sectional studies, and certainty of the evidence was assessed using the GRADE approach. Five cross-sectional studies published between 2008 and 2024, conducted in Turkey and Brazil, were included. One hundred ninety-nine SCD individuals were evaluated and the samples varied in terms of SCD genotype. The RMIs assessed were the mandibular cortical index, mandibular cortical width (MCW), panoramic mandibular index (PMI). FDA was applied in 03 studies. All studies had a risk of bias exceeding 25%, indicating low methodological quality.

conclusionsRMI and FDA show potential as adjunctive screening tools in patients with SCD. However, due to methodological heterogeneity and very low certainty of evidence, their clinical applicability remains limited.

Indexed as

Anemia, Sickle CellBone DensityMandibleFractalsHumansRadiography, Panoramicanemiafractal analysishemoglobin SC diseasemandibular cortical indexsickle cellsickle cell trait

Identifiers

PMID42117234
PMCPMC13162086

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.