ArticleOxford medical case reports2026
Sarcomatoid cutaneous squamous cell carcinoma of the heel: a rare localization of an aggressive variant of cutaneous squamous cell carcinoma.
Article in Oxford medical case reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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4 authors.
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Abstract
Sarcomatoid cutaneous squamous cell carcinoma (SCSCC) is a rare and aggressive variant of squamous cell carcinoma characterized by spindle-cell morphology resulting from epithelial-mesenchymal transition rather than true biphasic differentiation. Its sarcomatoid component may mimic other spindle-cell neoplasms, making diagnosis challenging. We report a 63-year-old chronic smoker presenting with a giant, rapidly enlarging ulcerated tumour of the left heel, initially misdiagnosed as a callus and later as Kaposi sarcoma and melanoma. Imaging showed no metastasis. The patient underwent wide trans-calcaneal resection with prophylactic inguinal lymph-node dissection. Histology demonstrated a high-grade spindle-cell malignancy expressing epithelial markers (CK5/6, AE1/AE3, p63) with negativity for specific melanocytic markers, confirming SCSCC (pT4N0, AJCC 8th edition). After 3 months of follow-up, no recurrence or metastasis was observed. This case highlights diagnostic pitfalls and the importance of comprehensive immunohistochemistry and multidisciplinary management.
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