ArticleBrain communications2026
Methodology for human-induced pluripotent stem cell-derived excitatory and inhibitory neuron coculture with astrocytes for Alzheimer's disease modelling.
Article in Brain communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Alzheimer's disease symptoms include gradual cognitive decline and memory loss that is correlated with progressive loss of neuronal connections due to an imbalance of excitatory and inhibitory synaptic functions. These have been shown in various rodent models but direct measurements of excitatory-inhibitory changes have yet to be performed in human neurons. Therefore, our project aims to construct a human-induced pluripotent stem cell co-culture model representing important brain circuitry which captures synaptic dysfunction. Familial Alzheimer's disease patient induced pluripotent stem cells carrying mutant
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