ArticleClinical ophthalmology (Auckland, N.Z.)2026
Correlation Analysis of Bowman's Layer Microdistortions and Corneal Biomechanics Changes Evaluated by Brillouin Microscopy After KLEx.
Article in Clinical ophthalmology (Auckland, N.Z.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose: To investigate the correlation between Bowman's layer microdistortions and the changes in corneal biomechanics evaluated by Brillouin microscopy after Keratorefractive Lenticule Extraction (KLEx). Methods: This study included forty-three right eyes that underwent KLEx, with a mean spherical equivalent of -5.89 ± 1.44 diopters. Metric M, the total width of the microdistortions, was calculated to indicate the quantity of Bowman's layer microdistortions according to the images measured using Fourier-domain optical coherence tomography (FD-OCT) 1month postoperatively. Corneal biomechanical metrics were obtained and analyzed using Brillouin microscopy preoperatively and 1 month postoperatively. Results: Bowman's layer microdistortions were observed using FD-OCT one month postoperatively, revealing a total width of 502 (175, 698) μm of the four meridians. Central, mean, minimum (Min), maximum (Max), and spatial standard deviation (SSD) Brillouin modulus (BM) quantified by Brillouin microscopy were 2.888 ± 0.074 GPa, 2.878 ± 0.041 GPa, 2.783 ± 0.059 GPa, 2.956 ± 0.053 GPa, 0.217 ± 0.063 GPa before KLEx, respectively; these changed to 2.800 ± 0.058 GPa (P <0.001), 2.821 ± 0.033 GPa (P <0.001), 2.734 ± 0.040 GPa (P <0.001), 2.908 ± 0.051 GPa (P <0.001), 0.223 ± 0.062 GPa (P =0.666) 1 month after KLEx, respectively. Metric M was correlated with value's changes of Mean BM (r =0.57, P <0.001*) and Min BM (r =0.35, P =0.02), controlling for spherical equivalent. Conclusion: In this study, the alterations in corneal biomechanics following KLEx are positively correlated with the range of Bowman's layer microdistortions. Increased Bowman's layer microdistortions may lead to a more pronounced decline in the corneal biomechanics. These findings may be useful for evaluating KLEx outcomes, detecting complications early, and optimizing patient monitoring.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.