ReviewJournal of extracellular biology2026
Exercise and Skeletal Muscle-Derived Extracellular Vesicles: Their Cargo, Release, and Role in Metabolic Regulation.
Review in Journal of extracellular biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Exercise-mediated extracellular vesicle-derived non-coding RNAs and cardiovascular protection: mechanistic insights and bibliometric analysis.Frontiers in physiology · 2026Pooled it
- Exercise-responsive endocrine-metabolic mediators in diabetes and cardiometabolic disorders: a systematic scoping review and evidence map.Frontiers in endocrinology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
The health benefits of exercise are well established in the prevention and management of metabolic disorders such as obesity and diabetes. Emerging evidence indicates that extracellular vesicles (EVs) may contribute to the beneficial effects of exercise. These membrane-bound nanoparticles carry bioactive molecules, such as proteins, lipids, and RNAs, and facilitate intercellular communication. Of note, exercise has been shown to significantly influence EV release and cargo, enhancing their ability to mediate metabolic benefits across various tissue types. Recent investigations have demonstrated that skeletal muscle-derived EVs (SkM-EVs) can improve insulin sensitivity, promote glucose homeostasis, and modulate lipid metabolism in recipient cells and tissues. Additionally, exercise-induced SkM-EVs are enriched in specific proteins and microRNAs that activate key signaling pathways essential for glucose homeostasis, thereby providing protective effects against insulin resistance, inflammation, and other hallmarks of metabolic dysfunction. In this review, we summarise the current understanding of the effects of exercise on SkM-EV release, molecular cargo, and the potential mechanisms by which they exert metabolic benefits. By doing so, we highlight the potential of SkM-EVs as therapeutic tools for treating diabetes and related metabolic disorders.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.