Evidence map›Paper›PMID 42116918›Full record

ArticleSurgical neurology international2026

Frontoparietal astroblastoma with MN:1BEND2 fusion in a young woman: A case report.

Amna Arshad Saroya, Zainab Haider Ejaz, Usman Attique, Aisha Hassan Memon, Shayan Sirat Maheen Anwar, Akbar Ali Khan

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PubMed Full text at PMC Publisher
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Article in Surgical neurology international, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Amna Arshad SaroyaMedical College, Aga Khan University, Karachi, Pakistan.
Zainab Haider EjazMedical College, Aga Khan University, Karachi, Pakistan.
Usman AttiqueDepartment of Pathology and Laboratory Medicine, Section of Histopathology, Karachi, Pakistan.
Aisha Hassan MemonDepartment of Pathology and Laboratory Medicine, Section of Histopathology, Karachi, Pakistan.
Shayan Sirat Maheen AnwarDepartment of Radiology, Section of Neuroradiology, Aga Khan University Hospital, Karachi, Pakistan.
Akbar Ali KhanDepartment of Surgery, Section of Neurosurgery, Maroof International Hospital, Islamabad, Pakistan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Meningioma 1 (gene) (MN1)-altered astroblastoma is a rare central nervous system (CNS) lesion with variable and unpredictable morphology. Mainly affecting female children and young adults, it is believed to comprise only 0.45-2.8% of all neuroglial tumors. Case Description: Herein, we present the case of a 21-year-old female who complained of diplopia and severe left-sided weakness for a month. Following a detailed molecular analysis, she was diagnosed with right frontoparietal MN1-altered astroblastoma, with MN1-BEN domain containing 2 (gene) fusion. She underwent surgical resection and fully recovered from her symptoms. Conclusion: This case report offers additional insights into cerebral MN1-astroblastoma, with a specific focus on its presentation in South Asian young adult patients. It emphasizes the importance of advanced molecular diagnostics for the correct classification of CNS tumors, to fully understand this rare but potentially aggressive pathology.

Indexed as

AstroblastomaImmunohistochemistryMolecular oncologyMolecular profilingNeuroglia

Identifiers

PMID42116918
PMCPMC13157917

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