ArticleSurgical neurology international2026
Intramedullary spinal cord metastasis from vaginal high-grade neuroendocrine carcinoma: A case report.
Article in Surgical neurology international, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Intramedullary spinal cord metastases (ISCMs) from vaginal high-grade neuroendocrine carcinomas (VHNCs) are rare and may mimic primary intramedullary tumors or vascular lesions. Hereby, we report a 54-year-old female who presented with an ISCM attributed to a VHNC. Case Description: A 54-year-old female patient presented with a 1-month history of progressive left-predominant paraparesis, new-onset urinary incontinence, and constipation. She was previously diagnosed with a VHNC (i.e., small-cell carcinoma), with supraclavicular nodal metastasis, and had received cisplatin-etoposide chemotherapy 11 months earlier. The contrast-enhanced thoracolumbar magnetic resonance imaging (MRI) revealed an expansile intramedullary lesion at the T11-T12 level, with a focal, nodular, enhancing component, and surrounding edema. The patient subsequently underwent a near-total resection through a T11-T12 laminectomy. The postoperative MRI demonstrated a small residual lesion with an approximately 4-mm enhancing focus. Histopathology confirmed a metastatic high-grade neuroendocrine carcinoma consistent with the patient's known vaginal primary. The patient's neurological function had improved at the 3-month follow-up. Conclusion: ISCM may represent a critical neurologic complication of VHNC. Timely surgical decompression can facilitate neurological recovery and support multimodal oncologic management.
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