ArticleEuropean journal of oral sciences2026
Effects of triethylene glycol dimethacrylate and bisphenol A-glycidyl methacrylate on annexin A proteins in human mesangial cells.
Article in European journal of oral sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Dental resin monomers are widely used in restorative dentistry, yet their potential effects on kidney-related cell types remain poorly understood. This study investigated the effects of bisphenol A-glycidyl methacrylate (Bis-GMA) and triethylene glycol dimethacrylate (TEGDMA) on protein expression and cytoskeletal regulatory pathways in human mesangial cells. A proteomic analysis demonstrated differential expression of multiple members of the annexin A protein family in treated human mesangial cells compared with vehicle-treated controls. These findings were validated by western blotting and densitometric analysis, which revealed reduced expression of annexin A proteins, including annexin A2 and annexin A5, following exposure to TEGDMA. To further explore the functional relevance of annexin A2, transient knockdown using small interfering RNA was performed. Reduction of annexin A2 expression using siRNA resulted in decreased levels of alpha-smooth muscle actin and non-muscle myosin proteins compared with cells transfected with non-targeting control RNA. Collectively, these results indicate that commonly used dental resin monomers may influence protein expression and cytoskeletal-associated pathways in human mesangial cells through alterations in annexin A protein expression. The findings highlight a previously underexplored cellular response to dental methacrylates and suggest potential implications for renal cell biology under controlled in vitro conditions.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.