ArticleChemistry & biodiversity2026
Molecular Mechanistic Studies on Caffeoylquinic Acid Derivatives From Vaccinium dunalianum Wight as Dual-Target Inhibitors of AChE and BChE With In Vitro Inhibitory Evaluation and Molecular Docking.
Kang-Jia Han, Yu-Xiu Lv, Dong Xie, Li-Hua Zou, Qian Jiang, Si-Da Xie, Ying-Jun Zhang, Ping Zhao, Xiao-Qin Yang, Seng-Kew Wee
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In one paragraphArticle in Chemistry & biodiversity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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10 authors.
Kang-Jia HanKey Laboratory of Ministry of Education for Forest Resources Conservation and Utilization in the Southwest Mountains of China, Southwest Forestry University, Kunming, P.R. China.ORCID https://orcid.org/0009-0004-1880-5496 Yu-Xiu LvKey Laboratory of Ministry of Education for Forest Resources Conservation and Utilization in the Southwest Mountains of China, Southwest Forestry University, Kunming, P.R. China.
Dong XieKey Laboratory of Ministry of Education for Forest Resources Conservation and Utilization in the Southwest Mountains of China, Southwest Forestry University, Kunming, P.R. China.
Li-Hua ZouKey Laboratory of Ministry of Education for Forest Resources Conservation and Utilization in the Southwest Mountains of China, Southwest Forestry University, Kunming, P.R. China.
Qian JiangKey Laboratory of Ministry of Education for Forest Resources Conservation and Utilization in the Southwest Mountains of China, Southwest Forestry University, Kunming, P.R. China.
Si-Da XieKey Laboratory of Ministry of Education for Forest Resources Conservation and Utilization in the Southwest Mountains of China, Southwest Forestry University, Kunming, P.R. China.
Ying-Jun ZhangLaboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, P.R. China.
Ping ZhaoKey Laboratory of Ministry of Education for Forest Resources Conservation and Utilization in the Southwest Mountains of China, Southwest Forestry University, Kunming, P.R. China.
Xiao-Qin YangKey Laboratory of Ministry of Education for Forest Resources Conservation and Utilization in the Southwest Mountains of China, Southwest Forestry University, Kunming, P.R. China.ORCID https://orcid.org/0000-0003-4095-2017 Seng-Kew WeeFaculty of Bioengineering and Technology, University of Malaysia Kelantan, Kota Bharu, Malaysia.
Funding
National Natural Science Foundation of China 22267018National Natural Science Foundation of China 32060327Young and Middle-Aged Academic and Technological Leaders of Yunnan Province 202205AC160049Yunnan Foreign Expert Program 202505AO120060Yunnan Fundamental Research Projects 202401AT070295Yunnan Fundamental Research Projects 202501BD070001-027Yunnan Fundamental Research Projects 202503AC100002
6 · The paper itselfAbstract
Alzheimer's disease (AD) involves impaired cholinergic neurotransmission, so inhibiting acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) is a major treatment strategy. Vaccinium dunalianum Wight leaf extracts, abundant in caffeoylquinic acids (CQAs), potently inhibit AChE (IC
Indexed as
AcetylcholinesteraseButyrylcholinesteraseCholinesterase InhibitorsMolecular Docking SimulationQuinic AcidVacciniumAnimalsDose-Response Relationship, DrugHumansKineticsMolecular StructurePC12 CellsPlant ExtractsPlant LeavesRatsStructure-Activity RelationshipAcetylcholinesteraseButyrylcholinesterasecaffeoylquinic acidCholinesterase InhibitorsPlant ExtractsQuinic AcidAlzheimer's diseaseCQAsdual‐target inhibitormolecular dockingVaccinium dunalianum wight
Identifiers
PMID42116632
PMCPMC13376691
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