ArticlePlant, cell & environment2026
miR164c-CUC2 Module Modulates Salinity Stress Tolerance in Soybean by Regulating Abscisic Acid Signalling and Reactive Oxygen Species Scavenging Pathways.
Article in Plant, cell & environment, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- miR164c-CUC2 Module Modulates Salinity Stress Tolerance in Soybean by Regulating Abscisic Acid Signalling and Reactive Oxygen Species Scavenging Pathways.Plant, cell & environment · 2026Article
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Authors and funding
16 authors.
Funding
Abstract
Soil salinisation-induced salinity stress severely inhibits soybean growth and development. MicroRNA164 (miR164) modulates plant responses to salinity stress; however, the underlying regulatory mechanism remains unclear. In this study, using a field salinity pond system and CRISPR/Cas9 multiplex editing, we found that gma-miR164c knockout increased salt sensitivity, while overexpression improved tolerance. A comprehensive analysis showed that the NAC transcription factor family member CUP-SHAPED COTYLEDON 2 (GmCUC2) is a target of gma-miR164c. GmCUC2 overexpression compromised plant tolerance to salinity stress. gma-miR164c mutation downregulated the expression of genes involved in the abscisic acid (ABA) signalling pathway and reactive oxygen species (ROS) scavenging system. Co-expression analysis indicated that GmCUC2 expression negatively correlated with the expression of these genes. Dual-luciferase assays showed that two regulators of ABA signalling, namely, C2-DOMAIN ABA-RELATED PROTEIN 1 (GmCAR1) and C2-DOMAIN ABA-RELATED PROTEIN 2 (GmCAR2) are targets of GmCUC2; in fact, their overexpression improves salinity stress tolerance. Additionally, GmCUC2 repressed GmCAR1 and GmCAR2 expression, whereas gma-miR164c mitigated this inhibitory effect. These findings show that gma-miR164c suppresses its target gene GmCUC2, which is a negative regulator of ABA signalling and ROS scavenging, thereby enhancing soybean salinity tolerance. This study expands relevant mechanistic insights and provides genetic resources for breeding salt-tolerant varieties.
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