ArticleMedicine2026
Current status and perspectives of psychological & behavioral interventional clinical trials (PBCTs) for cancer-related distress: A systematic scoping review of ClinicalTrials.gov.
Article in Medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
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Corrections and comments
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Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCancer is one of the chronic diseases that has a debilitating effect on the mental health of patients as well as their caregivers. Psychological and behavioral interventions are used to alleviate distress symptoms. The present study aimed to review registered clinical trials on psychological and behavioral interventions used to treat cancer-related distress.
methodsThe current study employs the Preferred Reporting Items for Systematic reviews and Meta-Analyses extension for guideline. All interventional clinical trials registered at ClinicalTrials.gov for cancer-related distress were searched as of March 31, 2025. Boolean operators "AND/OR" were used to refine the search. The initial search yielded 341 results, which were reduced to 83 by applying a methodological filter, and only 36 trials fulfilled the inclusion criteria. Only registered trials that use psychological and behavioral interventions to alleviate cancer distress conducted with the adult population were included in the study.
resultsAs of September 30, 2025, 36 clinical trials in the ClinicalTrials.gov registry fulfilled inclusion criteria. All registered trials were analyzed qualitatively and quantitatively. Of 36 trials, almost 63.9% have been completed. 75% of studies utilize parallel randomized trials, where 50% of registered trials use Open-label masking. 27.8% of trials utilize the psychoeducational approach to deal cancer-related distress. 61.1% interventions were delivered individually within a clinical setting (66.7%). Moreover, the study identified 6 themes: managing distress, using innovative techniques, personalized care, culturally sensitive approaches, integrated care, and optimizing healing mechanisms.
conclusionThe progress of inclusive and flexible therapies must continue to advance if psychosocial support is to be completely incorporated into cancer treatment. Patients' overall well-being can be improved by increasing accessibility and efficacy through interdisciplinary teamwork and culturally sensitive techniques. The findings support improving the psychological well-being of cancer patients and caregivers through policy reforms and research priorities.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.