SynthesisMedicine2026
A meta-analysis of the efficacy and safety of Janus kinase inhibitors in patients with ulcerative colitis.
Synthesis in Medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundUlcerative colitis (UC) is a chronic inflammatory bowel disease characterized by relapsing intestinal inflammation and substantial impairment of quality of life. Janus kinase (JAK) inhibitors are orally administered small-molecule agents that interfere with intracellular cytokine signaling pathways central to UC pathogenesis. This systematic review and meta-analysis aimed to assess the therapeutic benefits and safety profile of JAK inhibitors in adults with moderate-to-severe UC.
methodsA systematic literature search was conducted in PubMed (from inception to November 2025), Embase, the Cochrane Library, and Web of Science to identify placebo-controlled RCTs evaluating JAK inhibitors in adult patients with UC. The primary efficacy outcomes were clinical remission and clinical response. Secondary outcomes included endoscopic remission, endoscopic response, and mucosal healing. Safety was assessed by the incidence of any adverse events (AEs). Pooled risk ratios (RRs) with 95% confidence intervals (CIs) were calculated using fixed- or random-effects models as appropriate. Statistical heterogeneity was evaluated using the I2 statistic, and subgroup analyses were performed according to treatment phase.
resultsNine publications encompassing 14 placebo-controlled RCT datasets met the inclusion criteria. Compared with placebo, JAK inhibitors significantly increased rates of clinical remission (RR = 2.48, 95% CI: 1.64-3.73) and clinical response (RR = 2.53, 95% CI: 1.73-3.70), although moderate-to-high heterogeneity was observed. Endoscopic outcomes were also markedly improved, with higher rates of endoscopic remission (RR = 3.52, 95% CI: 2.55-4.86) and mucosal healing (RR = 2.60-2.79 across models). Safety analyses demonstrated no significant difference in the overall incidence of adverse events between JAK inhibitors and placebo. Subgroup analyses revealed consistent efficacy during both induction and maintenance phases, with comparable safety profiles across treatment periods.
conclusionJAK inhibitors provide significant improvements in both clinical and endoscopic outcomes for patients with moderate-to-severe UC without increasing the overall risk of adverse events in short-term trials. These findings support the clinical utility of JAK inhibitors in UC management, while highlighting the need for long-term studies to better characterize rare and delayed safety signals.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.