Observational studyMedicine2026
Neutrophil extracellular traps and severe mycoplasma pneumonia: A clinical observational study.
Observational study in Medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Neutrophil extracellular traps biomarkers are associated with lung function obstruction severity in bronchial asthma.The Journal of international medical research · 2026Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
backgroundThis full-scale confirmatory study aimed to measure serum neutrophil extracellular traps (NETs) levels in children with severe Mycoplasma pneumoniae pneumonia (SMPP) and non-severe MPP, and to compare the predictive performance of serum NETs, C-reactive protein (CRP), and lactate dehydrogenase (LDH) for SMPP.
methodsA total of 200 children hospitalized with MPP between January 2023 and August 2024 were consecutively enrolled and divided into SMPP (n = 100) and non-severe MPP (n = 100) groups. Baseline demographic and laboratory indices were compared between groups. Receiver operating characteristic (ROC) curves were used to assess predictive value, and univariate and multivariate logistic regression were performed to identify independent predictors of SMPP.
resultsAge and sex distributions were comparable between groups (all P > .05). Serum white blood cell count, neutrophil ratio, CRP, D-dimer, LDH, and NETs were significantly higher in the SMPP group (all P < .001). ROC analysis showed serum NETs had the highest area under the curve (AUC = 0.83, 95% confidence interval [CI]: 0.762-0.896), with a cutoff value of 19.2, sensitivity 0.818, and specificity 0.835. Multivariate logistic regression confirmed serum NETs (odds ratio [OR] = 4.32, 95% CI: 3.45-7.25, P = .023), CRP (OR = 3.62, 95% CI: 1.85-9.25, P = .010), and LDH (OR = 1.63, 95% CI: 1.18-2.26, P = .001) as independent predictors of SMPP.
conclusionSerum NETs are strongly elevated in children with SMPP and show better predictive performance than conventional CRP and LDH. Combined measurement of NETs, CRP, and LDH provides a reliable tool for the early identification of pediatric SMPP. This study extends and validates our preliminary exploratory findings with a larger sample and complete statistical analysis.
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