Evidence map›Paper›PMID 42116231›Full record

ArticleAngewandte Chemie (International ed. in English)2026

A Deep-Red-Absorbing Osmium(II) Complex as a Photosensitizer for Photodynamic Therapy Inducing Immunogenic Cell Death.

Yiyi Zhang, Pierre Mesdom, Eduardo Izquierdo-García, João P M António, Ruonan Gao, Bruno Saubaméa, Johanne Seguin, Morgane Moinard, Philippe Arnoux, Céline Frochot and 3 more

Abstract read
In one paragraph

Article in Angewandte Chemie (International ed. in English), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Yiyi ZhangChimie ParisTech, PSL University, CNRS, Institute of Chemistry for Life and Health Sciences, Laboratory For Inorganic Chemical Biology, Paris, France.ORCID 0000-0002-7572-5685
Pierre MesdomChimie ParisTech, PSL University, CNRS, Institute of Chemistry for Life and Health Sciences, Laboratory For Inorganic Chemical Biology, Paris, France.ORCID 0000-0003-1069-2138
Eduardo Izquierdo-GarcíaChimie ParisTech, PSL University, CNRS, Institute of Chemistry for Life and Health Sciences, Laboratory For Inorganic Chemical Biology, Paris, France.ORCID 0000-0002-7253-6934
João P M AntónioChimie ParisTech, PSL University, CNRS, Institute of Chemistry for Life and Health Sciences, Laboratory For Inorganic Chemical Biology, Paris, France.ORCID 0000-0002-0144-694X
Ruonan GaoChimie ParisTech, PSL University, CNRS, Institute of Chemistry for Life and Health Sciences, Laboratory For Inorganic Chemical Biology, Paris, France.ORCID 0009-0007-8969-0819
Bruno SaubaméaCellular and Molecular Imaging Platform (PICMO), US 25 Inserm, UAR 3612 CNRS, Faculté de Pharmacie de Paris, Université Paris Cité, Paris, France.ORCID 0000-0002-6218-0460
Johanne SeguinUniversité Paris Cité, CNRS, Inserm, Unité de Technologies Chimiques et Biologiques pour la Santé (UTCBS), Paris, France.
Morgane MoinardUniversité De Lorraine, CNRS, LRGP, Nancy, France.
Philippe ArnouxUniversité De Lorraine, CNRS, LRGP, Nancy, France.
Céline FrochotUniversité De Lorraine, CNRS, LRGP, Nancy, France.
Kevin CariouChimie ParisTech, PSL University, CNRS, Institute of Chemistry for Life and Health Sciences, Laboratory For Inorganic Chemical Biology, Paris, France.ORCID 0000-0002-5854-9632
Bich-Thuy DoanChimie ParisTech, PSL University, CNRS, Institute of Chemistry for Life and Health Sciences, Laboratory of Synthesis, Electrochemistry, Imaging and Analytical Systems For Diagnosis, Paris, France.ORCID 0000-0002-1961-9175
Gilles GasserChimie ParisTech, PSL University, CNRS, Institute of Chemistry for Life and Health Sciences, Laboratory For Inorganic Chemical Biology, Paris, France.ORCID 0000-0002-4244-5097

Funding

China Scholarship CouncilERC Consolidator GA 681679
6 · The paper itself

Abstract

Immunogenic cell death (ICD), which converts tumor cells into their own vaccine, plays a pivotal role in the development of novel anticancer therapies. Here, a small series of osmium(II) polypyridyl complexes was synthesized, and their biological activity in the dark and upon light irradiation against various cancer cell lines was studied. The compound Os2 (bearing two 4,7-diphenyl-1,10-phenanthrolines and one substituted bipyridine ligand) was discovered to be the most effective photosensitizer (PS) for photodynamic therapy (PDT) of this series through the photogeneration of

Indexed as

Antineoplastic AgentsCoordination ComplexesImmunogenic Cell DeathOsmiumPhotochemotherapyPhotosensitizing AgentsAnimalsCell Line, TumorHumansMiceRed LightAntineoplastic AgentsCoordination ComplexesOsmiumPhotosensitizing Agentsadaptive immunityimmunogenic cell deathmetals in medicineosmiumphotodynamic therapy

Identifiers

PMID42116231
PMCPMC13327620

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.