ArticleChinese medicine2026
Data-driven full-chain quality control for Xiaoer Chiqiao Qingre granules: from process risk management to intelligent product testing.
Article in Chinese medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Yangxin Tongluo Decoction Protects Against Sepsis-Associated Cardiac Dysfunction Through Regulating Nrf2 Pathway.Mediators of inflammation · 2026Article
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9 authors.
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Abstract
backgroundXiaoer Chiqiao Qingre granules (XECQ) is a widely used traditional Chinese medicine for the treatment of pediatric wind-heat colds. However, its multi-step manufacturing process results in substantial inter-batch variability, posing a challenge for consistent quality control. Guided by the Quality by Design (QbD) concept, this study developed an integrated framework that combines process analysis, parameter optimization, and intelligent monitoring to improve batch-to-batch consistency and ensure medication safety.
methodsWithin the QbD framework, HPLC-based multi-component quantification, chromatographic fingerprinting, and physical fingerprinting were employed to monitor quality across the entire manufacturing process, including extraction, concentration, alcohol precipitation, and decoction collection. Eleven active constituents were quantitatively characterized, and their relationships with key physicochemical properties were analyzed. The retention rates of terpenoids, flavonoids, and phenylethanoid glycosides were defined as critical quality attributes (CQAs). Critical process parameters were screened using a Plackett-Burman design, and the design space for the alcohol precipitation process was established through Box-Behnken response surface methodology. In addition, a machine vision system was developed for rapid, non-destructive evaluation of particle appearance.
resultsAlcohol precipitation resulted in the greatest loss among the 11 monitored components, with an average reduction of 23.6%, whereas maackiain-7-O-glucoside exhibited a marked decrease of 38.1% during the concentration stage. After alcohol precipitation, the concentration factors of flavonoids, phenylethanoid glycosides, and terpenoids were 1.56, 1.53, and 1.50, respectively, suggesting a negative correlation between retention rate and compound polarity. Component redistribution during processing significantly reduced the relative standard deviation (RSD) of viscosity, indicating improved system homogeneity and a reversal of component-property correlations. Using these representative components as CQAs, robust regression models (Adj R
conclusionThis study proposes a holistic "Process Analysis-Parameter Optimization-Intelligent Monitoring" strategy, providing a robust framework for enhancing the quality control of XECQ and facilitating the transition of TCM manufacturing from empirically driven practices to data-driven processes.
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