Evidence map›Paper›PMID 42116198›Full record

ReviewJournal of translational medicine2026

Foundation models in healthcare: a comprehensive review from technical advances to clinical translation.

Zhaoying Wang, Yuanyuan Fang, Qi Li

Abstract readReview
In one paragraph

Review in Journal of translational medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Zhaoying WangDepartment of Medical Oncology, Cancer Center, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, China.
Yuanyuan FangThe Hong Kong University of Science and Technology (Guangzhou), Guangzhou, China.
Qi LiDepartment of Medical Oncology, Cancer Center, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, China. leeqi@sjtu.edu.cn.ORCID 0000-0002-2978-2339

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAs artificial intelligence (AI) has evolved through a series of discrete leaps, the Foundation model (FM) has demonstrated substantial potential for applications in the medical domain. Built on scalability, multimodal processing, and adaptability to diverse downstream tasks, FMs offer a flexible framework that can be tailored to various clinical needs. Nevertheless, the translation of FMs into clinical practice remains challenged by concerns regarding data privacy and security, bias and fairness, interpretability and sustainability. Therefore, a clinically oriented review is needed not only to summarize current advances and limitations but also to emphasize the clinical relevance, practical significance, and translational implications of FMs in medicine. MAIN BODY: This review outlines the development history of AI and introduces the FM basic theory, summarizes recent advances in their medical applications, and examines how FMs may support clinicians, enhance workflow efficiency, and improve patient outcomes. In addition to summarizing existing work, this review places particular emphasis on the clinical relevance, practical significance, and translational challenges of FMs across healthcare. Furthermore, privacy, safety, transparency, computational resources, clinical feasibility and sustainability issues are further discussed. Finally, the future direction of FMs in the medical field was projected.

conclusionA central concept of this review is that the clinical translation of FMs requires interdisciplinary collaboration among AI developers, clinicians, and policymakers, supported by careful evaluation frameworks and continuous oversight to ensure clinical benefit and minimize risk.

Indexed as

Delivery of Health CareModels, TheoreticalTranslational Research, BiomedicalArtificial IntelligenceHumansArtificial intelligenceFoundation modelsGenerative artificial intelligenceLarge models

Identifiers

PMID42116198
PMCPMC13330362

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.