Nanoengineered bile acid-mediated orchestration of versatile immuno-microbial cues for treating periodontitis.

Shuang Li, Lu Lin, Mengmeng Zhang, Jinyao Liu, Eryi Lu, Zhenping Cao

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Article in Journal of nanobiotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

6 authors.

Shuang LiDepartment of Stomatology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200127, China.

Lu LinDepartment of Stomatology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200127, China.

Mengmeng ZhangState Key Laboratory of Systems Medicine for Cancer, Shanghai Key Laboratory for Nucleic Acid Chemistry and Nanomedicine, Institute of Molecular Medicine, Renji Hospital, School of Medicine, Shanghai Cancer Institute, Shanghai Jiao Tong University, Shanghai, 200127, China.

Jinyao LiuState Key Laboratory of Systems Medicine for Cancer, Shanghai Key Laboratory for Nucleic Acid Chemistry and Nanomedicine, Institute of Molecular Medicine, Renji Hospital, School of Medicine, Shanghai Cancer Institute, Shanghai Jiao Tong University, Shanghai, 200127, China. jyliu@sjtu.edu.cn.

Eryi LuDepartment of Stomatology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200127, China. lueryi222@126.com.

Zhenping CaoState Key Laboratory of Systems Medicine for Cancer, Shanghai Key Laboratory for Nucleic Acid Chemistry and Nanomedicine, Institute of Molecular Medicine, Renji Hospital, School of Medicine, Shanghai Cancer Institute, Shanghai Jiao Tong University, Shanghai, 200127, China. caozhenping@renji.com.

Funding

China Postdoctoral Science Foundation 2022M710748National Science Foundation of China 22575146National Science Foundation of China 52171075National Science Foundation of China 82401198Natural Science Foundation of Shanghai 25ZR1401224the Youth Science and Technology Talents-the Sailing program of Shanghai 22YF1439400

6 · The paper itself

Abstract

Periodontitis, a globally prevalent inflammatory disease, is propelled by a vicious cycle involving microbial dysbiosis, hyperactive host immune responses, excessive oxidative stresses, and chronic inflammations. Current treatments largely focus on reducing microbial pathogens, yielding limited therapeutic efficacy. Here, we report a polydopamine-based taurolithocholic acid (TLCA) nanotherapeutic (PDCA) that reprograms versatile immuno-microbial cues to ameliorate periodontal inflammation and restore tissue homeostasis. Leveraging the dual function of polydopamine in drug delivery and redox capacity, after cellular uptake, PDCA scavenges reactive oxidation species, and releases TLCA to interact with its nuclear receptors in various target cells, exerting multifaceted regulatory effects. In inflamed human gingival fibroblasts, PDCA reduces the oxidative stress and enriches intracellular accumulation of TLCA to assist its interaction with vitamin D receptor, thus attenuating the expression of pro-inflammatory cytokines. Furthermore, PDCA modulates hyperactive immune responses, including suppressing the maturation of dendritic cells, inhibiting osteoclast differentiation of monocytes, downregulating pro-inflammatory CD4

Indexed as

Bile Acids and SaltsPeriodontitisAnimalsGingivaHumansIndolesMiceMicrobiotaOxidative StressPolymersBile Acids and SaltsIndolespolydopaminePolymersBile acid nanomedicineImmunomodulationMicrobiome regulationPeriodontal inflammatory diseasesPolydopamine

Identifiers

PMID42116157

DOI10.1186/s12951-026-04495-y

PMCPMC13335026

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LicenceCC BY-NC-ND

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.