Evidence map›Paper›PMID 42116152›Full record

SynthesisJournal of neuroengineering and rehabilitation2026

Multimodal colour modulation for cognitive enhancement in intelligent rehabilitation: a systematic review and translational guidance.

Lina Xu, Xingkai Wang, Wenan Li, Yuyang Jiang, Chen Cheng, Zhenhong Li, Yuyang Wang, Luwen Yu

Abstract readSystematic Review
In one paragraph

Synthesis in Journal of neuroengineering and rehabilitation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Lina XuComputational Media and Arts thrust, The Hong Kong University of Science and Technology (Guangzhou), No.1 Du Xue Rd, Nansha District, Guangzhou, Guangdong, China. lxu582@connect.hkust-gz.edu.cn.
Xingkai WangComputational Media and Arts thrust, The Hong Kong University of Science and Technology (Guangzhou), No.1 Du Xue Rd, Nansha District, Guangzhou, Guangdong, China.
Wenan LiComputational Media and Arts thrust, The Hong Kong University of Science and Technology (Guangzhou), No.1 Du Xue Rd, Nansha District, Guangzhou, Guangdong, China.
Yuyang JiangThe Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong SAR, China.
Chen ChengThe Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong SAR, China.
Zhenhong LiDepartment of Electrical and Electronic Engineering, The University of Manchester, Manchester, M1 3BB, UK.
Yuyang WangComputational Media and Arts thrust, The Hong Kong University of Science and Technology (Guangzhou), No.1 Du Xue Rd, Nansha District, Guangzhou, Guangdong, China.
Luwen YuComputational Media and Arts thrust, The Hong Kong University of Science and Technology (Guangzhou), No.1 Du Xue Rd, Nansha District, Guangzhou, Guangdong, China. luwenyu@hkust-gz.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundColour modulation has been investigated as a non-invasive means of supporting cognitive performance, yet translation to rehabilitation-oriented applications has been constrained by fragmented evidence, inconsistent parameterisation, and heterogeneous assessment strategies. MAIN BODY: This systematic review synthesises 75 studies published between 2011 and 2025 through a Colour-Modality-Cognition framework that links stimulus design, measurement strategy, and cognitive goals. Across the evidence base, a graded and context-dependent pattern emerged. Contrast-related variables, particularly lightness and colour difference, showed more consistent support for baseline legibility and task reachability, whereas hue- and chroma-related effects were more conditional on task family, visual context, implementation locus, and the baseline contrast conditions already in place. Across several studies, efficiency-related changes, including shorter search times or reduced cortical load, were more readily captured by ocular and neurophysiological measures than by behavioural outcomes alone, especially where behavioural performance approached ceiling levels. However, the literature rarely assessed post-training retention, transfer, or other longer-term rehabilitation-relevant outcomes.

conclusionCurrent evidence supports a more explicit framework for the design and evaluation of rehabilitation-oriented colour interventions, particularly in relation to contrast-secured visual design and the use of multimodal assessment. However, implications for adaptive rehabilitation systems remain preliminary because most available evidence derives from controlled, predominantly non-clinical task settings rather than direct rehabilitation deployment.

Indexed as

Cognitive EnhancementColor PerceptionNeurological RehabilitationColorHumansCognitive enhancementColour modulationIntelligent rehabilitationMultimodal assessmentSystematic review

Identifiers

PMID42116152
PMCPMC13335281

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.