ArticleMolecular brain2026
Modulation of BK-like potassium currents by ketamine in rat cochlear outer hair cells.
Article in Molecular brain, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Ketamine is widely used as an anesthetic agent, yet its cellular effects on the auditory system, particularly on cochlear outer hair cells (OHCs), remain incompletely understood. In this study, we investigated the electrophysiological effects of ketamine on isolated OHCs from young Sprague Dawley rats using whole-cell patch-clamp techniques. OHCs were acutely dissociated and exposed to ketamine at varying concentrations to evaluate its impact on membrane currents. Ketamine produced a dose- and voltage-dependent reduction in outward membrane currents, particularly at membrane potentials more positive than -36 mV. Pharmacological blockade with iberiotoxin and ion substitution experiments using intracellular Cs
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