Evidence map›Paper›PMID 42116089›Full record

ArticleJournal of experimental & clinical cancer research : CR2026

Exosomal NEAT1 from tumor stem cells induces SIRPA

Nanheng Yin, Zhicheng Zhang, Feiyu Xia, Xiaopei Zhang, Zengyang Li, Tao Zhong, Jiaxin Pan, Geng Liang, Delong Huang, Xiaoxiao Dai and 1 more

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In one paragraph

Article in Journal of experimental & clinical cancer research : CR, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Nanheng Yin *Department of Neurosurgery, The Second Affiliated Hospital of Soochow University, Suzhou, 215004, China.
Zhicheng Zhang *Department of Neurosurgery, The Second Affiliated Hospital of Soochow University, Suzhou, 215004, China.
Feiyu Xia *Department of Neurosurgery, The Second Affiliated Hospital of Soochow University, Suzhou, 215004, China.
Xiaopei ZhangDepartment of Neurosurgery, The Second Affiliated Hospital of Soochow University, Suzhou, 215004, China.
Zengyang LiDepartment of Neurosurgery, The Second Affiliated Hospital of Soochow University, Suzhou, 215004, China.
Tao ZhongDepartment of Neurosurgery, The Second Affiliated Hospital of Soochow University, Suzhou, 215004, China.
Jiaxin PanDepartment of Neurosurgery, The Second Affiliated Hospital of Soochow University, Suzhou, 215004, China.
Geng LiangDepartment of Neurosurgery, The Second Affiliated Hospital of Soochow University, Suzhou, 215004, China.
Delong HuangDepartment of Neurosurgery, The Second Affiliated Hospital of Soochow University, Suzhou, 215004, China.
Xiaoxiao DaiDepartment of Pathology, The Second Affiliated Hospital of Soochow University, Suzhou, China.
Jun DongDepartment of Neurosurgery, The Second Affiliated Hospital of Soochow University, Suzhou, 215004, China. dongjun@suda.edu.cn.

Funding

National Natural Science Foundation of China 82473127
6 · The paper itself

Abstract

backgroundSignal Regulatory Protein Alpha (SIRPA) functions as an inhibitory receptor to suppress phagocytosis of macrophages and promote tumor immune evasion. Recent studies revealed that SIRPA deficiency reprogrammed tumor-associated macrophages toward an antitumor phenotype, and SIRPA functioned independently of CD47. However, the exact role and signaling pathways by which SIRPA

methodsPublic single-cell RNA sequencing datasets were analyzed to identify SIRPA

resultsBioinformatic analysis of single-cell datasets identified a distinct subset of SIRPA

conclusionsGSC-derived exosomal NEAT1 reprogrammed macrophages toward an immunosuppressive SIRPA

Indexed as

Brain NeoplasmsExosomesGlioblastomaHSP90 Heat-Shock ProteinsMacrophagesNeoplastic Stem CellsReceptors, ImmunologicRNA, Long NoncodingSTAT3 Transcription FactorAnimalsCell Line, TumorCell ProliferationDisease ProgressionFemaleGene Expression Regulation, NeoplasticHumansHSP90 Heat-Shock ProteinsNEAT1 long non-coding RNA, humanReceptors, ImmunologicRNA, Long NoncodingSTAT3 protein, humanSTAT3 Transcription FactorExosomal lncRNA NEAT1GlioblastomaMacrophagesTumor stem cells

Identifiers

PMID42116089
PMCPMC13330394

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.