Evidence map›Paper›PMID 42116076›Full record

ArticleHuman genomics2026

Single-cell RNA-sequencing reveals cellular heterogeneity and identifies biomarkers for obstructive sleep apnea and migraine.

Qipeng Cen, Youfeng Xie, Wenyi Song, Tingting Cao, Qingyan Wei, Guining Liang, Lucong Liang, Chun Zou, Rongjie Li, Mika Pan and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Human genomics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Qipeng Cen *Department of Neurology, The Second Affiliated Hospital of Guangxi Medical University, No. 166 Daxuedong Road, Nanning, 530007, Guangxi, China.
Youfeng Xie *Department of Neurology, The Second Affiliated Hospital of Guangxi Medical University, No. 166 Daxuedong Road, Nanning, 530007, Guangxi, China.
Wenyi Song *Department of Neurology, The Second Affiliated Hospital of Guangxi Medical University, No. 166 Daxuedong Road, Nanning, 530007, Guangxi, China.
Tingting CaoDepartment of Neurology, The Second Affiliated Hospital of Guangxi Medical University, No. 166 Daxuedong Road, Nanning, 530007, Guangxi, China.
Qingyan WeiDepartment of Neurology, The Second Affiliated Hospital of Guangxi Medical University, No. 166 Daxuedong Road, Nanning, 530007, Guangxi, China.
Guining LiangDepartment of Neurology, The Second Affiliated Hospital of Guangxi Medical University, No. 166 Daxuedong Road, Nanning, 530007, Guangxi, China.
Lucong LiangDepartment of Neurology, The Second Affiliated Hospital of Guangxi Medical University, No. 166 Daxuedong Road, Nanning, 530007, Guangxi, China.
Chun ZouDepartment of Neurology, The Second Affiliated Hospital of Guangxi Medical University, No. 166 Daxuedong Road, Nanning, 530007, Guangxi, China.
Rongjie LiDepartment of Geriatrics, The Fifth Affiliated Hospital of Guangxi Medical University, Nanning, 530021, Guangxi, China.
Mika PanDepartment of Neurology, The Second Affiliated Hospital of Guangxi Medical University, No. 166 Daxuedong Road, Nanning, 530007, Guangxi, China. panmika1106@163.com.
Li SuDepartment of Neurology, Affiliated Hospital of Youjiang Medical University for Nationalities, No. 98 Chengxiang Road, Baise, 533000, Guangxi, China. suli307@126.com.
Donghua ZouDepartment of Neurology, The Second Affiliated Hospital of Guangxi Medical University, No. 166 Daxuedong Road, Nanning, 530007, Guangxi, China. zoudonghua@gxmu.edu.cn.

Funding

Guangxi Natural Science Foundation 2025GXNSFAA069366the Joint Project on Regional High-Incidence Diseases Research of Guangxi Natural Science Foundation 2024GXNSFDA010001
6 · The paper itself

Abstract

backgroundObstructive sleep apnea (OSA), a prevalent sleep disorder associated with migraine, has unclear effects on cellular heterogeneity within this comorbid context.

resultsA total of 75,502 cells from five cell types were identified from OSA and non-OSA samples (GSE214865), while 20,243 cells from four cell types were identified from migraine and healthy control samples (GSE269117). T cells were the most abundant immune cells in patients with OSA and migraine. HIF-1/NF-κB signaling had significant activity. FOS, FOSB, PDE3B, KLF6, RPS26, MTRNR2L8, MT-ATP8, PLCG2, and CCR7 were the key biomarkers of both OSA and migraine. A TCMNP software-based network was constructed with drug prediction revealed significant associations between Ma Huang and Bai Guo and their active components TCM00192 and TCM02096. Natural killer T cells were the least differentiated subtype and were inferred to be the starting point, closely connected to CD8

conclusionSingle-cell RNA analysis revealed a shared T cell-centered immune-dysregulated landscape in OSA and migraine, identifying common biomarkers and key pathways. These findings provide a crucial foundation for understanding comorbidities and developing new therapies.

Indexed as

BiomarkersMigraine DisordersSingle-Cell AnalysisSleep Apnea, ObstructiveHumansSequence Analysis, RNASignal TransductionSingle-Cell Gene Expression AnalysisBiomarkersBiomarkersCellular heterogeneityDrug predictionMigraineObstructive sleep apnea

Identifiers

PMID42116076
PMCPMC13335133

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.