Evidence map›Paper›PMID 42116050›Full record

ArticleThrombosis journal2026

Incidence and risk factors of deep vein thrombosis in critically ill patients: a systematic review and meta-analysis.

Tian Zuo, Jiajun Yu, Xin Yin, Hanliang Wu, Shuai Mao

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Article in Thrombosis journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

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5 authors.

Tian Zuo *Intensive Care Unit, Ersha Island Hospital, Guangdong Provincial Hospital of Chinese Medicine, The Second Clinical College of Guangzhou University of Chinese Medicine, No. 261 Datong Road, Ersha Island, Guangzhou, 510105, China.
Jiajun Yu *Traditional Chinese Medicine Department, The Eighth Affiliated Hospital, Sun Yat-sen University (FuTian, Shenzhen), Shenzhen, 518000, China.
Xin YinIntensive Care Unit, Ersha Island Hospital, Guangdong Provincial Hospital of Chinese Medicine, The Second Clinical College of Guangzhou University of Chinese Medicine, No. 261 Datong Road, Ersha Island, Guangzhou, 510105, China.
Hanliang WuIntensive Care Unit, Liwan Central Hospital, Guangzhou, 510170, China.
Shuai MaoIntensive Care Unit, Ersha Island Hospital, Guangdong Provincial Hospital of Chinese Medicine, The Second Clinical College of Guangzhou University of Chinese Medicine, No. 261 Datong Road, Ersha Island, Guangzhou, 510105, China. maoshuai@gzucm.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDeep vein thrombosis (DVT) is a frequent and often silent complication in intensive care unit (ICU) patients, markedly increasing the risk of pulmonary embolism and death. However, comprehensive quantitative evidence on ICU-DVT incidence and associated risk factors remains scarce.

objectiveTo synthesize global data on the epidemiology of ICU-DVT and identify independent risk factors, providing a basis for evidence-based, risk-stratified prevention.

methodsWe systematically searched PubMed, Embase, Cochrane Library, and Web of Science to July 2024 for observational studies reporting ICU-DVT incidence and risk factors. Pooled odds ratios (ORs) were calculated using random-effects models (PROSPERO ID: CRD42024583844).

resultsA total of 186 studies were included, involving 203,880 ICU patients. The overall incidence of DVT was 10.4% (95% CI 8.9%-12.0%). The incidence was significantly higher in COVID-19 patients than in non-COVID-19 patients (12.4% vs. 8.4%, p < 0.01). Medical ICUs had the highest incidence (16.3%), followed by trauma ICUs (11.6%), general ICUs (10.1%), neuro ICUs (8.6%), and surgical ICUs (7.9%). The incidence varied by region (Asia 12.5%, Europe 11.8%; America 9.3%, Oceania 9.1%). Systematic screening significantly improved DVT detection rates compared with clinically suspected diagnosis (14.6% vs. 7.9%). Meta-analysis revealed that central venous catheterization, a history of DVT, use of vasoactive agents, mechanical ventilation, prolonged ICU stay, and malignancy were associated with increased DVT odds.

conclusionsICU-DVT affects approximately 1 in 10 patients and is associated with distinct modifiable and non-modifiable risk factors. The influence of diagnostic strategies on DVT incidence underscores the necessity for standardized screening in the ICU. Future prospective, large-scale studies are warranted to validate causal relationships and enable the development of risk prediction tools for precision prevention.

Indexed as

Deep vein thrombosisIntensive care unitMeta-analysisRisk factors

Identifiers

PMID42116050
PMCPMC13335205

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.