Folic acid-modified antigen-trapping nanoprobes for developing in situ tumor vaccines to inhibit metastasis and recurrence of ovarian cancer.

Xiaowen Zhong, Tao Pu, Ying Cheng, Yan Li, Qi Wang, Bin Wang

Abstract read

In one paragraph

Article in Journal of nanobiotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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0 citing papers in PubMed.

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4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Xiaowen ZhongDepartment of Anesthesiology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400042, P. R. China. zhongxiaowen1993@163.com.

Tao PuDepartment of Anesthesiology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400042, P. R. China.

Ying ChengDepartment of Anesthesiology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400042, P. R. China.

Yan LiDepartment of Anesthesiology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400042, P. R. China.

Qi WangState Key Laboratory of Ultrasound in Medicine and Engineering, Chongqing Medical University, Chongqing, 400016, P. R. China.

Bin WangDepartment of Anesthesiology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400042, P. R. China. 774935778@qq.com.

Funding

China Postdoctoral Science Foundation 2024M763899National Natural Science Foundation of China 82403889

6 · The paper itself

Abstract

Tumor vaccines hold promise in inhibiting tumor metastasis and recurrence by stimulating the immune system to target and eliminate heterogeneous tumors. However, the development of optimal strategies for in situ tumor vaccines and the establishment of reliable methods to ensure their efficacy remain challenges. In this study, we engineered a folate-modified antigen-trapping nanoprobe (AGO@FA-lip). This nanoprobe initially acquires tumor antigens and double-stranded DNA (dsDNA) by inducing immunogenic cell death in tumor cells through the DNA-damaging agent oxaliplatin (OXA). Nano-aluminum hydroxide (nano-Al(OH)

Indexed as

Antigens, NeoplasmCancer VaccinesFolic AcidNanoparticlesOvarian NeoplasmsAnimalsCell Line, TumorDendritic CellsFemaleHumansImmunotherapyMiceNeoplasm MetastasisNeoplasm Recurrence, LocalTumor MicroenvironmentAntigens, NeoplasmCancer VaccinesFolic AcidAntigen captureChemoimmunotherapyIn situ tumor vaccinesOvarian cancerTumor microenvironment

Identifiers

PMID42116044

DOI10.1186/s12951-026-04537-5

PMCPMC13335270

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LicenceCC BY

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.