Evidence map›Paper›PMID 42116023›Full record

ArticleBMC pediatrics2026

Evaluating the impact of pulmonary metastasectomy prior to liver transplantation in pediatric hepatoblastoma patients.

Takeshi Saito, Akihiro Yoneda, Yuki Yamamoto, Tetsuya Ishimaru, Naoki Shimojima, Kimikazu Matsumoto, Hajime Uchida, Seisuke Sakamoto, Mureo Kasahara

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC pediatrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Takeshi SaitoDivision of Pediatric Surgery, Department of Pediatric Surgical Specialties, National Center for Child Health and Development, 2-10-1, Okura, Setagaya-Ku, Tokyo, 1578535, Japan.
Akihiro YonedaDivision of Pediatric Surgery, Department of Pediatric Surgical Specialties, National Center for Child Health and Development, 2-10-1, Okura, Setagaya-Ku, Tokyo, 1578535, Japan. yoneda-a@ncchd.go.jp.
Yuki YamamotoDivision of Pediatric Surgery, Department of Pediatric Surgical Specialties, National Center for Child Health and Development, 2-10-1, Okura, Setagaya-Ku, Tokyo, 1578535, Japan.
Tetsuya IshimaruDivision of Pediatric Surgery, Department of Pediatric Surgical Specialties, National Center for Child Health and Development, 2-10-1, Okura, Setagaya-Ku, Tokyo, 1578535, Japan.
Naoki ShimojimaDivision of Pediatric Surgery, Department of Pediatric Surgical Specialties, National Center for Child Health and Development, 2-10-1, Okura, Setagaya-Ku, Tokyo, 1578535, Japan.
Kimikazu MatsumotoChildren's Cancer Center, National Center for Child Health and Development, 2-10-1, Okura, Setagaya-Ku, Tokyo, 1578535, Japan.
Hajime UchidaCenter for Organ Transplantation, National Center for Child Health and Development, 2- 10-1, Okura, Setagaya-Ku, Tokyo, 1578535, Japan.
Seisuke SakamotoCenter for Organ Transplantation, National Center for Child Health and Development, 2- 10-1, Okura, Setagaya-Ku, Tokyo, 1578535, Japan.
Mureo KasaharaCenter for Organ Transplantation, National Center for Child Health and Development, 2- 10-1, Okura, Setagaya-Ku, Tokyo, 1578535, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeLiver transplantation (LT) has improved the outcomes of patients with unresectable hepatoblastoma; however, pulmonary metastases remain a major prognostic challenge. Therefore, we retrospectively evaluated the impact of pulmonary metastasectomy (PM) performed before LT.

methodsBetween November 2002 and November 2023, 15 children diagnosed with hepatoblastoma with pulmonary metastases underwent PM. All patients received preoperative chemotherapy. Patients requiring LT underwent PM prior to LT (pre-PM), whereas others underwent PM following hepatectomy (post-PM). Clinical characteristics, alpha-fetoprotein (AFP) levels, PM details, and recurrence rates were compared.

resultsThe pre-PM included 8 patients, and the post-PM included 7 patients. The median age at diagnosis was 26 and 40 months, with follow-up periods of 49 and 100 months, respectively. In the pre-PM, 5 patients (63%) required repeated PM after LT, with a median of 3 PMs; all experienced recurrence, and 4 (80%) developed uncontrolled pulmonary metastases. In the post-PM, the median number of PMs was 1; 3 patients (43%) experienced recurrence, but all achieved recurrence-free survival after repeated PM. No significant differences in the baseline characteristics were observed.

conclusionWhether PM prior to LT is truly beneficial remains to be determined, and further validation through the accumulation of additional cases is required.

Indexed as

HepatoblastomaLiver NeoplasmsLiver TransplantationLung NeoplasmsMetastasectomyChildChild, PreschoolFemaleFollow-Up StudiesHepatectomyHumansInfantMaleNeoplasm Recurrence, LocalRetrospective StudiesHepatoblastomaLiver resectionLiver transplantationMetastasis surgery.Pulmonary metastasectomy

Identifiers

PMID42116023
PMCPMC13335246

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.