Evidence map›Paper›PMID 42115834›Full record

ArticleAging cell2026

The MICOS Complex Regulates Mitochondrial Structure and Oxidative Stress During Age-Dependent Structural Deficits in the Kidney.

Prasanna Katti, Praveena Prasad, Sepiso K Masenga, Prasanna Venkhatesh, Zer Vue, Andrea G Marshall, Benjamin Rodriguez, Han Le, Edgar Garza-Lopez, Alexandria Murphy and 39 more

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Article in Aging cell, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

49 authors.

Prasanna KattiDepartment of Biology, Indian Institute of Science Education and Research (IISER), Tirupati, Andhra Pradesh, India.
Praveena PrasadDepartment of Biochemistry and Molecular Biology, The Huck Institute of the Life Sciences, Pennsylvania State University, University Park, Pennsylvania, USA.
Sepiso K MasengaDepartment of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee, USA.ORCID https://orcid.org/0000-0003-4376-5831
Prasanna VenkhateshDepartment of Biology, Indian Institute of Science Education and Research (IISER), Tirupati, Andhra Pradesh, India.ORCID https://orcid.org/0000-0003-3274-6192
Zer VueDepartment of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee, USA.
Andrea G MarshallDepartment of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee, USA.ORCID https://orcid.org/0000-0001-9997-4478
Benjamin RodriguezDepartment of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee, USA.
Han LeDepartment of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee, USA.
Edgar Garza-LopezDepartment of Internal Medicine, University of Iowa, Iowa City, Iowa, USA.
Alexandria MurphyDepartment of Biochemistry and Molecular Biology, The Huck Institute of the Life Sciences, Pennsylvania State University, University Park, Pennsylvania, USA.
Brenita JenkinsDepartment of Biochemistry and Molecular Biology, The Huck Institute of the Life Sciences, Pennsylvania State University, University Park, Pennsylvania, USA.
Ashlesha KadamDepartment of Internal Medicine, Section of Cardiovascular Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.
Jianqiang ShaoCentral Microscopy Research Facility, University of Iowa, Iowa City, Iowa, USA.
Amber CrabtreeDepartment of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee, USA.
Pamela MartinDepartment of Biomedical Sciences, School of Graduate Studies, Meharry Medical College, Nashville, Tennessee, USA.
Chantell EvansDepartment of Cell Biology, Duke University School of Medicine, Durham, North Carolina, USA.
Mark A PhillipsDepartment of Integrative Biology, Oregon State University, Corvallis, Oregon, USA.ORCID https://orcid.org/0000-0002-2319-7913
David HubertDepartment of Integrative Biology, Oregon State University, Corvallis, Oregon, USA.
Nelson WandiraDepartment of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.ORCID https://orcid.org/0009-0009-9063-0324
Okwute M OchayiDepartment of Human Physiology, Baze University, Abuja, Nigeria.ORCID https://orcid.org/0000-0002-1468-5579
Dhanendra TomarDepartment of Internal Medicine, Section of Cardiovascular Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.
Clintoria R WilliamsDepartment of Neuroscience, Cell Biology and Physiology, Wright State University, Dayton, Ohio, USA.
Jennifer GaddyDepartment of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Briar TomeauDepartment of Biomedical Sciences, School of Graduate Studies, Meharry Medical College, Nashville, Tennessee, USA.
LaCara BellDepartment of Biomedical Sciences, School of Graduate Studies, Meharry Medical College, Nashville, Tennessee, USA.
Taneisha GillyardDepartment of Biomedical Sciences, School of Graduate Studies, Meharry Medical College, Nashville, Tennessee, USA.ORCID https://orcid.org/0000-0002-4536-3724
Markis' HamiltonDepartment of Biomedical Sciences, School of Graduate Studies, Meharry Medical College, Nashville, Tennessee, USA.
Vineeta SharmaDepartment of Biochemistry, Cancer Biology, Neuroscience and Pharmacology, Meharry Medical College, Nashville, Tennessee, USA.
Mohd Mabood KhanDepartment of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee, USA.
Elma ZaganjorDepartment of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee, USA.
Olujimi A AjijolaUCLA Cardiac Arrhythmia Center, University of California, Los Angeles, California, USA.
Estevão ScudeseDepartment of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee, USA.
Tyne W Miller FlemingDepartment of Medicine, Division of Genetic Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
André KinderArtur Sá Earp Neto University Center - UNIFASE-FMP, Petrópolis Medical School, Rio de Janeiro, Brazil.
Chandravanu DashDepartment of Microbiology, Immunology and Physiology, School of Medicine, Meharry Medical College, Nashville, Tennessee, USA.
Anita M QuintanaDepartment of Biological Sciences, Border Biomedical Research Center, the University of Texas at El Paso, El Paso, Texas, USA.ORCID https://orcid.org/0000-0002-3596-1587
Bret C MobleyDepartment of Pathology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Julia D BerryDepartment of Pathology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Pooja JadiyaDepartment of Internal Medicine, Section of Gerontology and Geriatric Medicine, Sticht Center for Healthy Aging and Alzheimer's Prevention, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.
Dao-Fu DaiDepartment of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Annet KiraboDepartment of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee, USA.
Oleg KovtunDepartment of Chemistry, Vanderbilt University, Nashville, Tennessee, USA.ORCID https://orcid.org/0000-0001-6809-9332
Jenny C SchaferDepartment of Cell and Developmental Biology, Vanderbilt University, Nashville, Tennessee, USA.ORCID https://orcid.org/0000-0003-2505-5457
Sean SchafferDepartment of Cell and Developmental Biology, Vanderbilt University, Nashville, Tennessee, USA.
Renata Oliveira PereiraDepartment of Internal Medicine, Division of Endocrinology and Metabolism, Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA.
Debra D MurrayDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, USA.
Joyonna Gamble-GeorgeDepartment of Computer Science, Whiting School of Engineering, Johns Hopkins University, Baltimore, Maryland, USA.ORCID https://orcid.org/0000-0002-5492-9216
Melanie R McReynoldsDepartment of Biochemistry and Molecular Biology, The Huck Institute of the Life Sciences, Pennsylvania State University, University Park, Pennsylvania, USA.ORCID https://orcid.org/0000-0001-5427-2739
Antentor HintonDepartment of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee, USA.ORCID https://orcid.org/0000-0002-7730-952X

Funding

The RCMI Program in Health Disparities Research at Meharry Medical College - SupplementU54MD007586 · NIMHD · MEHARRY MEDICAL COLLEGE · PI Samuel Evans Adunyah · 2017 to 2026
$48.2M
Tennessee CFAR: Implementation of Culturally Responsive Trauma-Informed Care with Youth with HIV in Memphis, TNP30AI110527 · NIAID · VANDERBILT UNIVERSITY MEDICAL CENTER · PI John Koethe · 2015 to 2026
$27.5M
Role of GRIN2 in ART and SUD associated neurological deficits.R01DA057204 · NIDA · MEHARRY MEDICAL COLLEGE · PI Chandravanu Dash · 2022 to 2026
$3.7M
Spatiotemporal Staging of the HIV-1 Preintegration complexR01AI170228 · NIAID · MEHARRY MEDICAL COLLEGE · PI Chandravanu Dash · 2022 to 2026
$2.8M
Role of the Viral Capsid in HIV-1 IntegrationR01AI136740 · NIAID · MEHARRY MEDICAL COLLEGE · PI Chandravanu Dash · 2019 to 2026
$2.2M
Metabolic reprogramming and FGF21 signaling in kidney health and polycystic kidney diseasesR01DK133118 · NIDDK · UNIVERSITY OF IOWA · PI Dao-Fu Dai · 2022 to 2026
$2.0M
The role of the integrated stress response in brown adipose tissue-mediated metabolic adaptationsR01DK125405 · NIDDK · UNIVERSITY OF IOWA · PI PEREIRA ALAMBERT, RENATA · 2020 to 2024
$1.9M
Enhancing Virology Training of Underrepresented Minority Students through Summer ResearchR25AI164610 · NIAID · MEHARRY MEDICAL COLLEGE · PI DASH, CHANDRAVANU · 2021 to 2025
$1.8M
Chan Zuckerberg Initiative 2022-253529NIAID NIH HHS P30 AI110527NIAID NIH HHS R01 AI136740NIAID NIH HHS R01 AI170228NIAID NIH HHS R25 AI164610NIDA NIH HHS R01 DA057204NIDDK NIH HHS R01 DK125405NIDDK NIH HHS R01 DK133118NIMHD NIH HHS U54 MD007586
6 · The paper itself

Abstract

Due to aging, the efficiency of kidney function begins to decrease. Dysfunction in mitochondria and their cristae is a hallmark of aging. Therefore, age-related decline in kidney function could be attributed to changes in mitochondrial ultrastructure, increased reactive oxygen species, and alterations in metabolism and lipid composition. We sought to understand how mitochondrial ultrastructure is altered over time in tubular kidney cells. A serial block face-scanning electron microscope and manual segmentation using the Amira software were employed to visualize murine kidney samples during the aging process at 3 months (young) and 2 years (old). We found that 2-year mitochondria are more fragmented with many uniquely shaped mitochondria observed across aging, concomitant with shifts in ROS, metabolomics, and lipid homeostasis. Furthermore, we demonstrate that the mitochondrial contact site and cristae organizing system (MICOS) complex is impaired in the kidney during aging. Disruption of the MICOS complex resulted in altered mitochondrial metabolic function and increased ROS levels. We found significant, detrimental structural changes in the mitochondria of aged kidney tubules, suggesting a potential mechanism underlying the increased frequency of kidney disease with aging. We hypothesize that disruption of the MICOS complex exacerbates mitochondrial dysfunction, creating a vicious cycle of mitochondrial degradation and oxidative stress, which impacts kidney health.

Indexed as

AgingKidneyMitochondriaOxidative StressAnimalsMiceMice, Inbred C57BLReactive Oxygen SpeciesReactive Oxygen Species3DEMkidneymetabolismMICOS complexmitochondria

Identifiers

PMID42115834
PMCPMC13160932

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.