Evidence map›Paper›PMID 42115728›Full record

ArticleScientific reports2026

SPARC is associated with tumor nerve stroma interactions and perineural invasion in pancreatic ductal adenocarcinoma.

Satoru Furuhashi, Ryuta Muraki, Yoshifumi Morita, Daiki Nishiwaki, Akio Matsumoto, Yuji Shimizu, Tomohiro Murakami, Makoto Takeda, Hirotoshi Kikuchi, Yoshihiro Hiramatsu and 3 more

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In one paragraph

Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Satoru Furuhashi *Department of Surgery, Hamamatsu University School of Medicine, 1-20-1, Handayama, Chuou-ku, Hamamatsu, 431-3125, Shizuoka, Japan.
Ryuta Muraki *Department of Surgery, Hamamatsu University School of Medicine, 1-20-1, Handayama, Chuou-ku, Hamamatsu, 431-3125, Shizuoka, Japan.
Yoshifumi MoritaDepartment of Surgery, Hamamatsu University School of Medicine, 1-20-1, Handayama, Chuou-ku, Hamamatsu, 431-3125, Shizuoka, Japan. yoshi-mo@hama-med.ac.jp.
Daiki NishiwakiDepartment of Surgery, Hamamatsu University School of Medicine, 1-20-1, Handayama, Chuou-ku, Hamamatsu, 431-3125, Shizuoka, Japan.
Akio MatsumotoDepartment of Surgery, Hamamatsu University School of Medicine, 1-20-1, Handayama, Chuou-ku, Hamamatsu, 431-3125, Shizuoka, Japan.
Yuji ShimizuDepartment of Surgery, Hamamatsu University School of Medicine, 1-20-1, Handayama, Chuou-ku, Hamamatsu, 431-3125, Shizuoka, Japan.
Tomohiro MurakamiDepartment of Surgery, Hamamatsu University School of Medicine, 1-20-1, Handayama, Chuou-ku, Hamamatsu, 431-3125, Shizuoka, Japan.
Makoto TakedaDepartment of Surgery, Hamamatsu University School of Medicine, 1-20-1, Handayama, Chuou-ku, Hamamatsu, 431-3125, Shizuoka, Japan.
Hirotoshi KikuchiDepartment of Surgery, Hamamatsu University School of Medicine, 1-20-1, Handayama, Chuou-ku, Hamamatsu, 431-3125, Shizuoka, Japan.
Yoshihiro HiramatsuDepartment of Surgery, Hamamatsu University School of Medicine, 1-20-1, Handayama, Chuou-ku, Hamamatsu, 431-3125, Shizuoka, Japan.
Tomoaki KahyoDepartment of Cellular and Molecular Anatomy, Hamamatsu University School of Medicine, Hamamatsu, Japan.
Mitsutoshi SetouDepartment of Cellular and Molecular Anatomy, Hamamatsu University School of Medicine, Hamamatsu, Japan.
Hiroya TakeuchiDepartment of Surgery, Hamamatsu University School of Medicine, 1-20-1, Handayama, Chuou-ku, Hamamatsu, 431-3125, Shizuoka, Japan.

Funding

Japan Society for the Promotion of Science 20K22838
6 · The paper itself

Abstract

Perineural invasion (PNI) is frequent in pancreatic ductal adenocarcinoma (PDAC) and contributes to poor prognosis, yet stromal-neural mechanisms remain unclear. We developed a vertical multi-co-culture model incorporating human PDAC cells, neonatal mouse dorsal root ganglion (DRG) neurons, and human pancreatic stellate cells (PSCs). Migration assays demonstrated markedly greater PDAC cell migration in DRG + PSC than either condition alone. Proteomic profiling of conditioned media identified Secreted Protein Acidic and Rich in Cysteine (SPARC) as a highly enriched factor in the DRG + PSC condition. Public transcriptomic datasets (TCGA, GTEx, scRNA-seq) confirmed SPARC upregulation in PDAC, with predominant expression in fibroblasts and association with poor survival. Immunohistochemistry of 81 resected PDAC specimens in Hamamatsu University School of Medicine revealed stromal-rich SPARC expression significantly correlated with PNI-positive status. Collectively, these findings indicate that stromal SPARC is associated with PNI-related aggressiveness in PDAC. SPARC may serve as a biomarker of unfavorable prognosis and as a candidate stromal factor warranting future functional validation within the tumor-nerve-stromal axis.

Indexed as

Carcinoma, Pancreatic DuctalOsteonectinPancreatic NeoplasmsAnimalsCell Line, TumorCell MovementCoculture TechniquesFemaleGanglia, SpinalGene Expression Regulation, NeoplasticHumansMiceNeoplasm InvasivenessPancreatic Stellate CellsPeripheral NervesProteomicsOsteonectinSPARC protein, humanPancreatic ductal adenocarcinomaPerineural invasionProteomicsSPARCTumor microenvironment

Identifiers

PMID42115728
PMCPMC13442835

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.