ReviewPediatric research2026
Prenatal parental mental health and neurodevelopment in children with congenital heart disease.
Review in Pediatric research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Authors and funding
14 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Congenital heart disease (CHD) represents nearly 1% of live births and complex types are commonly diagnosed during the second trimester of pregnancy. The uncertainty related to a diagnosis of fetal CHD can have long-lasting effects on parental mental health ranging from anxiety and depressive symptoms to psychiatric disorders such as major depression and post-traumatic stress disorder. Recent data have outlined the deleterious impact of prenatal maternal stress on fetal brain development and neurodevelopmental outcomes in infancy regardless of a specific congenital anomaly. Specifically, infants with CHD are reported to have neurodevelopmental impairments in several domains such as motor, language and executive function skills with various degrees of severity. Neurological sequelae of complex CHD results from cumulative risk factors, including fetal cerebral hypoxia/hypoperfusion, surgical interventions, and socioeconomic status. Prenatal parental psychological distress may be a critical and potentially modifiable risk factor (i.e., amenable to prevention or remediation) for adverse neurodevelopmental outcomes in complex CHD. This current review presents existing knowledge on parental mental health and its relationship with neurological and developmental consequences in children with and without CHD. It will further outline future research strategies to enhance children with CHD long-term neurodevelopmental outcomes. IMPACT: This review presents current knowledge on the interplay between prenatal parental mental health and neurodevelopmental outcomes of children with complex congenital heart disease (CHD). It emphasizes prenatal psychological distress as a modifiable risk factor, highlighting opportunities for early preventive interventions. It advocates for future research aiming at improving long-term neurodevelopmental trajectories, moving beyond descriptive associations to concrete strategies for clinical practice and public policy.
Identifiers
42115723What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.