Evidence map›Paper›PMID 42115719›Full record

ArticleScientific reports2026

High expression of the underexplored SLC4A11 protein-coding transcript is specific to the corneal endothelium.

Elena S Kotova, Elena I Sharova, Polina A Kovaleva, Boris E Malyugin, Olga P Antonova, Alexandra V Belodedova, Ivan S Tkachenko, Yuriy V Doludin, Tatiana N Garmanova, Mikhail Protasov and 2 more

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In one paragraph

Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Biomolecules · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Elena S Kotova *Lopukhin Federal Research and Clinical Center of Physical-Chemical Medicine of Federal Medical Biological Agency, Malaya Pirogovskaya, 1a, Moscow, 119435, Russia. potamanthus@gmail.com.
Elena I Sharova *Lopukhin Federal Research and Clinical Center of Physical-Chemical Medicine of Federal Medical Biological Agency, Malaya Pirogovskaya, 1a, Moscow, 119435, Russia.
Polina A KovalevaLopukhin Federal Research and Clinical Center of Physical-Chemical Medicine of Federal Medical Biological Agency, Malaya Pirogovskaya, 1a, Moscow, 119435, Russia.
Boris E MalyuginThe Jules Stein Eye Institute, University of California at Los Angeles, 200 Stein Plaza, Los Angeles, CA, 90095, USA.
Olga P AntonovaDepartment of Anterior Segment Transplant and Optical Reconstructive Surgery, S. Fyodorov Eye Microsurgery Complex Federal State Institution, Beskoudnikovsky Boulevard, 59A, Moscow, 127486, Russia.
Alexandra V BelodedovaDepartment of Anterior Segment Transplant and Optical Reconstructive Surgery, S. Fyodorov Eye Microsurgery Complex Federal State Institution, Beskoudnikovsky Boulevard, 59A, Moscow, 127486, Russia.
Ivan S TkachenkoDepartment of Anterior Segment Transplant and Optical Reconstructive Surgery, S. Fyodorov Eye Microsurgery Complex Federal State Institution, Beskoudnikovsky Boulevard, 59A, Moscow, 127486, Russia.
Yuriy V DoludinNational Medical Research Center for Therapy and Preventive Medicine, Petroverigskyj Lane 10, bld.3, Moscow, 101990, Russia.
Tatiana N GarmanovaLomonosov Moscow State University, Lomonosovskiy Prospekt, 27 bld.10, Moscow, 119192, Russia.
Mikhail ProtasovLopukhin Federal Research and Clinical Center of Physical-Chemical Medicine of Federal Medical Biological Agency, Malaya Pirogovskaya, 1a, Moscow, 119435, Russia.
Tatiana R TsedilinaLopukhin Federal Research and Clinical Center of Physical-Chemical Medicine of Federal Medical Biological Agency, Malaya Pirogovskaya, 1a, Moscow, 119435, Russia.
Liubov O SkorodumovaLopukhin Federal Research and Clinical Center of Physical-Chemical Medicine of Federal Medical Biological Agency, Malaya Pirogovskaya, 1a, Moscow, 119435, Russia.

Funding

Russian Science Foundation grant № 22-75-10157State funding "Personalnyi onkopreparat" project, state registration number R&D 124031200002-3
6 · The paper itself

Abstract

Fuchs' endothelial corneal dystrophy (FECD) and congenital hereditary endothelial dystrophy (CHED) are corneal endothelial pathologies associated with SLC4A11 gene variants. The principal findings on the expression and function of SLC4A11 in the corneal endothelium have been based on studies of three major transcripts variants (v1, v2 and v3) and their protein products. We aimed to address gaps and resolve contradictions regarding the expression of SLC4A11. Our transcriptomic analysis revealed predominant expression of RefSeq-annotated protein-coding transcripts v6 and v3, but not v2 and v1, in the corneal endothelium of patients with FECD and controls. We also demonstrated the specificity of high SLC4A11 and major transcript expression to corneal endothelium. Using the 5' RACE method, we directly showed that the major transcription start site is at the beginning of v6, from which v3 with an extended 5'UTR is also transcribed. We estimated the fraction of v6 and v3 from the overall expression as 0.63 and 0.34, respectively. We also obtained evidence of full-length v6 expression in corneal endothelium and its ability to drive translation of the previously described v2M36 protein isoform. These findings provide new information on SLC4A11 gene expression and functional consequences of some genomic variants identified in patients with FECD.

Indexed as

Anion Transport ProteinsAntiportersCorneal Dystrophies, HereditaryEndothelium, CornealFuchs' Endothelial Dystrophy5' Untranslated RegionsGene Expression ProfilingGene Expression RegulationHumansRNA, Messenger5' Untranslated RegionsAnion Transport ProteinsAntiportersRNA, MessengerSLC4A11 protein, humanCongenital hereditary endothelial dystrophyCorneal endotheliumFuchs corneal dystrophySLC4A11Transcription initiation

Identifiers

PMID42115719
PMCPMC13351061

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.