Evidence map›Paper›PMID 42115557›Full record

ArticlePharmaceutical research2026

Lithocholic Acid-Derived Imidazolium Salts Suppress Breast Cancer Growth: In Vitro and In Vivo Evaluation.

Diana Sawicka, Anna Sadowska, Agnieszka Hryniewicka, Beata Skonieczna, Robert Milewski, Katarzyna Guzińska-Ustymowicz, Halina Car

Abstract read
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In one paragraph

Article in Pharmaceutical research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Diana SawickaDepartment of Experimental Pharmacology, Medical University of Bialystok, Szpitalna Street 37, 15-295, Bialystok, Poland. diana.sawicka@umb.edu.pl.ORCID http://orcid.org/0000-0002-6804-3459
Anna SadowskaDepartment of Experimental Pharmacology, Medical University of Bialystok, Szpitalna Street 37, 15-295, Bialystok, Poland.
Agnieszka HryniewickaDepartment of Organic Chemistry, Medical University of Bialystok, Mickiewicza Street 2A, 15-222, Bialystok, Poland.
Beata SkoniecznaDepartment of Experimental Pharmacology, Medical University of Bialystok, Szpitalna Street 37, 15-295, Bialystok, Poland.
Robert MilewskiDepartment of Experimental Pharmacology, Medical University of Bialystok, Szpitalna Street 37, 15-295, Bialystok, Poland.
Katarzyna Guzińska-UstymowiczDepartment of General Pathomorphology, Medical University of Bialystok, Waszyngtona Street 13, 15-269, Bialystok, Poland.
Halina CarDepartment of Experimental Pharmacology, Medical University of Bialystok, Szpitalna Street 37, 15-295, Bialystok, Poland.

Funding

Uniwersytet Medyczny w Bialymstoku SUB.24.206Uniwersytet Medyczny w Bialymstoku SUB.24.215Uniwersytet Medyczny w Bialymstoku SUB.25.206
6 · The paper itself

Abstract

purposeA series of imidazolium salts (IMS), substituted with lithocholic acid (LA) and alkyl chains of varying lengths (LA-1 to LA-10), were evaluated for their cytotoxic effects against breast cancer (BC).

methodsThe cytotoxic potential of the tested salts was assessed in estrogen-dependent (MCF-7) and non-estrogen-dependent (MDA-MB-231) cell lines, as well as in the cardiomyocyte cell line H9C2. The study was also conducted in vivo using a MCF-7 mouse xenograft model.

resultsThe cytotoxicity of IMS increased with the length of the aliphatic chain. A significant effect, compared with the reference drug, was observed for LA-7 and LA-8 (IC

conclusionsLA-based IMS demonstrate significant potential as chemotherapeutic agents for the treatment of breast cancer.

Indexed as

Antineoplastic AgentsBreast NeoplasmsImidazolesLithocholic AcidAnimalsApoptosisCell Line, TumorCell ProliferationDoxorubicinFemaleHumansMCF-7 CellsMDA-MB-231 CellsMiceMice, NudeMyocytes, CardiacAntineoplastic AgentsDoxorubicinImidazolesLithocholic Acidbreast cancercytotoxicitydoxorubicinimidazolium saltslithocholic acid

Identifiers

PMID42115557
PMCPMC13350105

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.