ArticleNatural products and bioprospecting2026
Four new Cyclohexenone with antibacterial activity from the coral-derived fungus Aspergillus flavus.
Article in Natural products and bioprospecting, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Marine fungus-derived natural products are an important source of new drugs and lead compounds. In this study, guided by the Global Natural Products Social (GNPS) molecular networking strategy, four new cyclohexenone derivatives, aspergiflones A-D (1-4), together with three known analogues (5-7), were isolated from the coral-derived fungus Aspergillus flavus. The structures of these compounds were elucidated through extensive spectroscopic analyses, comparison with literature data, hydrolysis reactions, quantum chemical calculations, and TDDFT-ECD calculations. Structurally, aspergiflone A (1) is a novel cyclohexenone dimer featuring an unprecedented skeleton in which two cyclohexenone units are connected at C-15 via a C-C single bond. Compound 1 exhibited potent antibacterial activity against Escherichia coli. Mechanism studies revealed that compound 1 disrupts bacterial cell morphology, increases cell membrane permeability, and decreases intracellular K
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