Evidence map›Paper›PMID 42115510›Full record

ArticleJournal of cardiovascular translational research2026

Ventricle-Specific Biomechanical Responses to Inotropic and Vasoactive Drugs in Human Myocardial Slices.

Sanne J J Langmuur, Jorik H Amesz, Rahi S Alipour Symakani, Kevin M Veen, Christiaan L Meuwese, Ad J J C Bogers, Natasja M S de Groot, Olivier C Manintveld, Yannick J H J Taverne

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cardiovascular translational research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Sanne J J LangmuurTranslational Cardiothoracic Surgery Research Lab, Department of Cardiothoracic Surgery, Erasmus Medical Center, P.O. Box 2040, 3000CA, Rotterdam, the Netherlands.
Jorik H AmeszTranslational Cardiothoracic Surgery Research Lab, Department of Cardiothoracic Surgery, Erasmus Medical Center, P.O. Box 2040, 3000CA, Rotterdam, the Netherlands.
Rahi S Alipour SymakaniDepartment of Experimental Cardiology, Erasmus Medical Center, Rotterdam, the Netherlands.
Kevin M VeenDepartment of Cardiothoracic Surgery, Erasmus Medical Center, Rotterdam, the Netherlands.
Christiaan L MeuweseDepartment of Intensive Care Adults, Erasmus Medical Center, Rotterdam, the Netherlands.
Ad J J C BogersDepartment of Cardiothoracic Surgery, Erasmus Medical Center, Rotterdam, the Netherlands.
Natasja M S de GrootTranslational Electrophysiology, Department of Cardiology, Erasmus Medical Center, Rotterdam, the Netherlands.
Olivier C ManintveldTransplant Institute, Erasmus Medical Center, Rotterdam, the Netherlands.
Yannick J H J TaverneTranslational Cardiothoracic Surgery Research Lab, Department of Cardiothoracic Surgery, Erasmus Medical Center, P.O. Box 2040, 3000CA, Rotterdam, the Netherlands. y.j.h.j.taverne@erasmusmc.nl.ORCID 0000-0002-1030-2198

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study aimed to compare baseline biomechanical contractile properties between right (RV) and left ventricular (LV) human living myocardial slices (LMS) and explore the effect of dobutamine, noradrenaline, adrenaline, levosimendan and enoximone in both ventricles. Sixty-three slices (33 RV, 30 LV) were produced from 5 explanted hearts. At baseline, RV LMS had a higher maximum contraction force, shorter contraction duration, time to peak and time to relaxation, steeper dF/dt and a larger peak area than LV LMS. Dobutamine administration had a larger effect in RV than LV LMS. Spontaneous, irregular contractions were observed after noradrenaline, adrenaline and dobutamine administration. In conclusion, RV LMS showed a stronger contraction with higher contraction velocity as compared to LV LMS and exhibited a greater response to dobutamine. These findings contribute to the understanding of the RV physiology as a separate entity, advocating for a different approach in treating RV or LV dysfunction.

Indexed as

Cardiotonic AgentsHeart VentriclesMyocardial ContractionVasoconstrictor AgentsVasodilator AgentsVentricular Function, LeftVentricular Function, RightAgedBiomechanical PhenomenaDobutamineFemaleHumansMaleMiddle AgedTime FactorsCardiotonic AgentsDobutamineVasoconstrictor AgentsVasodilator AgentsHeart failureLiving myocardial slicesRight ventricle

Identifiers

PMID42115510
PMCPMC13160974

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.