Evidence map›Paper›PMID 42115375›Full record

ReviewCellular and molecular life sciences : CMLS2026

Gastric intestinal metaplasia: unraveling the multifactorial pathogenesis and advancing risk stratification for gastric cancer prevention.

Yuxin He, Zilin Deng, Tongguo Shi, Weichang Chen

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Cellular and molecular life sciences : CMLS, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Yuxin HeJiangsu Institute of Clinical Immunology, The First Affiliated Hospital of Soochow University, Suzhou, China.
Zilin DengJiangsu Institute of Clinical Immunology, The First Affiliated Hospital of Soochow University, Suzhou, China.
Tongguo ShiJiangsu Institute of Clinical Immunology, The First Affiliated Hospital of Soochow University, Suzhou, China. shitg@suda.edu.cn.ORCID http://orcid.org/0000-0002-5382-2775
Weichang ChenDepartment of Gastroenterology, The First Affiliated Hospital of Soochow University, Suzhou, China. weichangchen@126.com.

Funding

Jiangsu Provincial Medical Key Discipline ZDXK202246National Natural Science Foundation of China 82073156National Natural Science Foundation of China 82270561Scientific research project of Jiangsu Provincial Health Commission K2025015
6 · The paper itself

Abstract

Gastric intestinal metaplasia (GIM) is a precancerous lesion characterized by the replacement of normal gastric mucosa with intestinal-type epithelium. As a critical intermediate stage in the Correa cascade, which is the established model of stepwise progression toward intestinal-type gastric cancer (GC), GIM represents a key window for clinical intervention. A comprehensive understanding of the molecular and histopathological features underlying GIM pathogenesis is therefore essential for improving patient stratification and outcomes. This review synthesizes current evidence regarding the histological classification and global epidemiology of GIM, then dissect the multifactorial risk factors and underlying pathogenic mechanisms, including the intricate interplay of Helicobacter pylori infection, host susceptibility, cellular reprogramming (with an emphasis on pyloric metaplasia and SPEM), microbial dysbiosis, and immune microenvironment alterations. Furthermore, we summarize validated and emerging biomarkers associated with GIM and their predictive value for malignant transformation. By navigating these complexities, this review aims to provide a foundational framework for advancing precision medicine approaches to intercept the metaplasia-carcinoma sequence and ultimately reduce the global burden of gastric cancer.

Indexed as

Gastric MucosaPrecancerous ConditionsStomach NeoplasmsAnimalsHelicobacter InfectionsHelicobacter pyloriHumansMetaplasiaRisk FactorsBiomarkerGastric cancerGastric intestinal metaplasiaPyloric metaplasia

Identifiers

PMID42115375
PMCPMC13333576

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.