ArticleScientific reports2026
In vivo evaluation of synthetic cannabinoid JWH-018 derivatives as potential new psychoactive substances.
Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Acute Toxicity of Three Synthetic Cannabinoids: First In Vivo Preclinical Study.Molecules (Basel, Switzerland) · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Synthetic cannabinoid receptor agonists constitute a prominent class of new psychoactive substances (NPS), in which minor structural modifications can markedly influence in vivo pharmacological outcomes. In this study, methoxy-substituted derivatives of JWH-018 were synthesized to examine the effect of substitution position on behavioral activity. JWH-018-5-OMe and JWH-018-6-OMe were evaluated using four in vivo assays, including catalepsy, hypothermia, analgesia, and locomotor activity. JWH-018-5-OMe selectively reduced rectal temperature, with limited effects observed in catalepsy, analgesia, and locomotor activity. Notably, JWH-018-6-OMe elicited robust and dose-dependent effects across all four behavioral endpoints, closely resembling the pharmacological profile of the parent compound, JWH-018. Collectively, these results demonstrate that structural variations on the indole scaffold can produce measurable psychoactive effects, underscoring the importance of continued evaluation of indole-based synthetic cannabinoids within the NPS framework.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.