Evidence map›Paper›PMID 42115276›Full record

ArticleScientific reports2026

A bioluminescent activity dependent platform, BLADe, for converting intracellular activity to photoreceptor activation.

Emmanuel L Crespo, Akash Pal, Mansi Prakash, Alexander D Silvagnoli, Zohair Zaidi, Manuel Gomez-Ramirez, Maya O Tree, Nathan C Shaner, Diane Lipscombe, Christopher I Moore and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Emmanuel L Crespo *College of Medicine, Central Michigan University, Mount Pleasant, MI, 48859, USA.
Akash Pal *College of Medicine, Central Michigan University, Mount Pleasant, MI, 48859, USA.
Mansi PrakashCollege of Medicine, Central Michigan University, Mount Pleasant, MI, 48859, USA.
Alexander D SilvagnoliCollege of Medicine, Central Michigan University, Mount Pleasant, MI, 48859, USA.
Zohair ZaidiDuke University, Undergraduate Neuroscience Program, Durham, NC, 27710, USA.
Manuel Gomez-RamirezDepartment of Neuroscience, Brown University, Providence, RI, 02912, USA.
Maya O TreeCollege of Medicine, Central Michigan University, Mount Pleasant, MI, 48859, USA.
Nathan C ShanerSchool of Medicine, Department of Neuroscience, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA, 92093-0662, USA.
Diane LipscombeDepartment of Neuroscience, Brown University, Providence, RI, 02912, USA.
Christopher I MooreDepartment of Neuroscience, Brown University, Providence, RI, 02912, USA. christopher_moore@brown.edu.
Ute HochgeschwenderCollege of Medicine, Central Michigan University, Mount Pleasant, MI, 48859, USA. hochg1u@cmich.edu.

Funding

BioLuminescent OptoGenetics (BL-OG): A Novel and Versatile Strategy for NeuromodulationU01NS099709 · NINDS · CENTRAL MICHIGAN UNIVERSITY · PI HOCHGESCHWENDER, UTE H, MOORE, CHRISTOPHER I · 2016 to 2018
$2.4M
Employing subcellular calcium to control membrane voltageR21EY026427 · NEI · CENTRAL MICHIGAN UNIVERSITY · PI HOCHGESCHWENDER, UTE H, LIPSCOMBE, DIANE · 2015 to 2016
$472k
Genetically Encoded Light-Production and Light-Sensing for Neuronal ManipulationR21MH101525 · NIMH · DUKE UNIVERSITY · PI HOCHGESCHWENDER, UTE H · 2013 to 2015
$434k
Selective dissection of local and distributed neocortical inhibitory circuits underlying sensory representationF99NS129170 · NINDS · CENTRAL MICHIGAN UNIVERSITY · PI CRESPO, EMMANUEL LUIS · 2022 to 2023
$80k
National Science Foundation CBET-1464686National Science Foundation DBI-1707352NEI NIH HHS R21 EY026427NIH HHS F99NS129170NIH HHS R21EY026427NIH HHS R21MH101525NIH HHS U01NS099709NIMH NIH HHS R21 MH101525NINDS NIH HHS F99 NS129170NINDS NIH HHS U01 NS099709
6 · The paper itself

Abstract

Genetically encoded sensors and actuators have advanced the ability to observe and manipulate cellular activity, yet few non-invasive strategies enable cells to directly couple their intracellular states to user-defined outputs. We promote a bioluminescent activity-dependent (BLADe) platform that facilitates programmable feedback through genetically encoded light generation. Using calcium (Ca

Indexed as

Luminescent MeasurementsPhotoreceptor CellsAnimalsCalciumLightLuciferasesNeuronsCalciumLuciferases

Identifiers

PMID42115276
PMCPMC13350893

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.