Evidence map›Paper›PMID 42115239›Full record

ArticleScientific reports2026

Effects of secretome derived from resveratrol treated mesenchymal stem cell on cornea wound: an organ culture study.

Fatemeh Rahimzadeh, Negar Abdollahzadeh, Benjamin Babaei, Seyede Atefe Hosseini, Fereshte Torabi, Amir Amani, Reza Salarinia

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Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Fatemeh RahimzadehStudent Research Committee, Faculty of Medicine, North Khorasan University of Medical Sciences, Bojnurd, Iran.
Negar AbdollahzadehStudent Research Committee, Faculty of Medicine, North Khorasan University of Medical Sciences, Bojnurd, Iran.
Benjamin BabaeiStudent Research Committee, Faculty of Medicine, North Khorasan University of Medical Sciences, Bojnurd, Iran.
Seyede Atefe HosseiniDepartment of Medical Biotechnology and Nanotechnology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Fereshte TorabiDepartment of Anatomy, Medicine Faculty, Mashhad University of Medical Sciences, Mashhad, Iran.
Amir AmaniNatural Products and Medicinal Plants Research Center, North Khorasan University of Medical Sciences, Bojnurd, Iran. amani76@gmail.com.
Reza SalariniaNatural Products and Medicinal Plants Research Center, North Khorasan University of Medical Sciences, Bojnurd, Iran. rezasalarinia@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The aim of this study was to improve of therapeutic effects of Adipose-Derived Stem Cells (ADSCs) secretome with Resveratrol (RV) treatment and investigate its effect on corneal wound healing. The ADSCs were isolated from the abdominal subcutaneous fat tissue of a rat and subsequntly cultured. Epidermal Growth Factor (EGF) and Hepatocyte Growth Factor (HGF) concentration were measured in secretome. Then, the effects of secretome treatment was assessed on rat cornea wound in ex-vivo model. The wound area and thickness of epithelial layer were measured and analyzed. The findings indicated that RV significantly increased the levels of HGF and EGF in the secretome. Furthermore, the secretome derived from RV-treated ADSCs resulted in a reduction of the corneal wound area and increased re-epithelialization. This study shown secretome derived from RV treated ADSCs can be effective for repair of cornea wound. Therefor, the RV treated stem cell approach hold promise to enhance the therapeutic effects of stem cell secretome.

Indexed as

Corneal InjuriesMesenchymal Stem CellsResveratrolSecretomeWound HealingAdipose TissueAnimalsCells, CulturedCorneaEpidermal Growth FactorHepatocyte Growth FactorMaleOrgan Culture TechniquesRatsRats, Sprague-DawleyEpidermal Growth FactorHepatocyte Growth FactorResveratrolAdipose-derived stem cellCorneal woundEpidermal growth factorHepatocyte growth factorResveratrolSecretome

Identifiers

PMID42115239
PMCPMC13350083

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.