ArticleNature communications2026
Conserved pathogenesis of ancestral and contemporary Oropouche virus strains in a murine pregnancy model.
Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- A framework for assessing potential Oropouche virus-associated adverse fetal outcomes.BMC infectious diseases · 2026Article
- Oropouche virus infection: clinical spectrum, geographic expansion, and emerging maternal-fetal implications.Infection · 2026Review
- Comparative analysis of host responses to Oropouche viruses in placental cell infection models.PLoS neglected tropical diseases · 2026Article
- Addressing Key Issues in Developing Safe and Effective Oropouche Virus Vaccines.Journal of medical virology · 2026Article
- Oropouche virus causes severe congenital disease in embryonic mice.Nature communications · 2026Article
- Oropouche virus causes acute hepatitis in mice controlled by type I interferons.Journal of virology · 2026Article
- Review
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Authors and funding
14 authors.
Funding
Abstract
Oropouche virus (OROV) is an emerging orthobunyavirus responsible for widespread outbreaks across South and Central America. Recent reports of congenital disease have raised urgent concerns regarding the potential risk of OROV infection during pregnancy. Here, we establish an in vivo murine model of OROV vertical transmission using the ancestral (prototype) strain BeAn19991 in immunocompetent C57BL/6 J mice. We demonstrate that OROV robustly replicates in maternal tissues and efficiently infects the placenta. Complementary studies in human trophoblast-derived cell lines demonstrate conserved placental tropism across both the ancestral strain and a contemporary (outbreak) isolate, supporting the translational relevance of our findings. Notably, comparison of ancestral and contemporary viruses indicates that placental infection is not a recently acquired property of OROV. Further, offspring born to infected dams exhibit maternally derived neutralizing antibodies and transient protection upon postnatal challenge. Together, these findings, considered alongside emerging epidemiological evidence, identify pregnancy as a critical context for OROV infection and underscore the need to evaluate risks to pregnant individuals in endemic regions.
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