Evidence map›Paper›PMID 42115103›Full record

ReviewTrends in cell biology2026

Precision in RNA degradation: helicases, ribosome and RNA polymerase stalling, and RNA modifications.

Daniel E Whisenant, Justine Soltys, Jerson D Estrella, Uttiya Basu

Abstract readReview
In one paragraph

Review in Trends in cell biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Daniel E WhisenantDepartment of Microbiology and Immunology, Vagelos College of Physicians and Surgeons, Columbia University, Irving Medical Center, New York, NY 10032, USA.
Justine SoltysDepartment of Microbiology and Immunology, Vagelos College of Physicians and Surgeons, Columbia University, Irving Medical Center, New York, NY 10032, USA.
Jerson D EstrellaDepartment of Microbiology and Immunology, Vagelos College of Physicians and Surgeons, Columbia University, Irving Medical Center, New York, NY 10032, USA.
Uttiya BasuDepartment of Microbiology and Immunology, Vagelos College of Physicians and Surgeons, Columbia University, Irving Medical Center, New York, NY 10032, USA. Electronic address: ub2121@cumc.columbia.edu.

Funding

Role of ncRNA Surveillance Complex "RNA Exosome" in Class Switch Recombination and Somatic HypermutationR01AI099195 · NIAID · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Uttiya Basu · 2012 to 2026
$9.8M
Long noncoding RNA expressing genomic element that control antibody diversification and chromosomal integrity in B cellsR01AI134988 · NIAID · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Uttiya Basu · 2018 to 2026
$4.7M
The role of N6-methyladenosine RNA modification in programmed and aberrant DNA mutagenesis in B cellsR01AI143897 · NIAID · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Uttiya Basu · 2020 to 2026
$3.4M
RNA associated mechanisms for antigen receptor gene diversification during immature B cell developmentR01AI178892 · NIAID · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Uttiya Basu · 2024 to 2026
$1.7M
Investigating the role of chromatin-associated RNA processing in Early B-cell developmentF31AI188882 · NIAID · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Daniel Eric Whisenant · 2025 to 2026
$100k
NIAID NIH HHS F31 AI188882NIAID NIH HHS R01 AI099195NIAID NIH HHS R01 AI134988NIAID NIH HHS R01 AI143897NIAID NIH HHS R01 AI178892
6 · The paper itself

Abstract

Errors in transcription and RNA processing generate aberrant transcripts that can produce truncated, nonfunctional, or dominant-negative proteins. RNA surveillance pathways, centered on the RNA exosome, recognize diverse processing defects and initiate targeted RNA degradation. These mechanisms also regulate the short half-life of chromatin-associated noncoding RNAs through co- and/or post-transcriptional degradation. This review examines how the RNA exosome achieves substrate specificity, focusing on its interactions with the helicase cofactors mRNA transport 4 (MTR4) and superkiller 2 (SKIV2L) and the modulatory role of RNA modifications such as N

Indexed as

DNA-Directed RNA PolymerasesRibosomesRNARNA HelicasesRNA StabilityAnimalsHumansRNA Processing, Post-TranscriptionalTranscription, GeneticDNA-Directed RNA PolymerasesRNARNA HelicasesMTR4ribosomesRNA exosomeRNA surveillanceSKI complextranscriptional stalling

Identifiers

PMID42115103
PMCPMC13677149

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.