ArticleeNeuro2026
Assessment of Cell-Type-Specific Excitatory Synaptic Strength in the Dorsolateral Striatum of Goal-Directed and Habitual Cocaine-Seeking Behavior.
Article in eNeuro, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 authors.
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Abstract
With repeated exposure to addictive drugs, there is a shift from drug abuse to drug addiction that is mediated by the transition from goal-directed to habitual control. It is well known that the development of habitual control over behavior relies upon cell-type-specific synaptic changes in both D1 and D2 medium spiny neurons (MSNs) in dorsal striatum. Specifically, habitual behavior is mediated by increased synaptic strength in D1 and D2 MSNs in dorsolateral striatum (DLS), suggesting similar cell-type-specific synaptic changes may underlie the development of habitual cocaine-seeking behavior. However, cell-type-specific synaptic changes have not been evaluated in DLS in this context. Therefore, we trained male rats to self-administer cocaine in a self-administration paradigm that allows for differentiation of goal-directed versus habitual cocaine-seeking behavior. Moreover, we used a viral vector under a D2-specific promoter to fluorescently label D2 MSNs with eYFP in DLS. Evoked excitatory postsynaptic currents (EPSCs) were used to determine AMPA:NMDA receptor ratio and the rectification index. Surprisingly, we did not observe any significant differences in these measures in DLS of cocaine-seeking rats, regardless of whether cocaine-seeking was under habitual control. Interestingly, preliminary observations revealed significant changes in the paired-pulse ratio (PPR), suggesting that presynaptic mechanisms may be involved in the development of habitual control over cocaine-seeking. Overall, however, these results suggest there are no changes in postsynaptic strength of D2 MSNs in the DLS of rats with an extended history of cocaine self-administration and regardless of whether the cocaine-seeking is under goal-directed or habitual control.
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