Evidence map›Paper›PMID 42114895›Full record

ArticleRMD open2026

Ultrasound assessment of vertebral ligaments: development and validation of a landmark-based scanning protocol with potential applicability in spondyloarthritis.

Chiara Rizzo, Luis Coronel, Maribel Miguel-Perez, David Bong, Juan Angel Patiño-Galindo, Mariona Colom, Diana Marcela Padilla-Ortiz, Plamen Todorov, Esther Francisca Vicente-Rabaneda, Stefano Alivernini and 4 more

Abstract readValidation Study
In one paragraph

Article in RMD open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

14 authors.

Chiara Rizzo *Instituto Poal de Reumatologia, Barcelona, Spain chiararizzo87@gmail.com.ORCID 0000-0003-4838-5854
Luis Coronel *Rheumatology Unit, Vall d'Hebron Hospital Universitari, Vall d'Hebron Barcelona Campus, Barcelona, Spain.ORCID 0000-0002-5460-864X
Maribel Miguel-PerezDepartment of Pathology and Experimental Therapeutics (Campus of Bellvitge), Unit of Human Anatomy and Embryology, University of Barcelona, Barcelona, Spain.
David BongDepartment of Pathology and Experimental Therapeutics (Campus of Bellvitge), Unit of Human Anatomy and Embryology, University of Barcelona, Barcelona, Spain.
Juan Angel Patiño-GalindoIMIDomics, Inc, Barcelona, Spain.
Mariona ColomRheumatology Research Group, Vall d'Hebron Research Institute, Barcelona, Spain.
Diana Marcela Padilla-OrtizInstituto Poal de Reumatologia, Barcelona, Spain.
Plamen TodorovDepartment of Internal Disease Propaedeutics and Rheumatology, Medical University of Plovdiv, Clinic of Rheumatology, University Hospital Kaspela, Plovdiv, Bulgaria.
Esther Francisca Vicente-RabanedaRheumatology Division, Hospital Universitario de La Princesa, IIS-Princesa, Universidad Autonoma de Madrid, Madrid, Spain.
Stefano AliverniniDivision of Rheumatology and Clinical Immunology, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy.ORCID 0000-0002-7383-4212
Pedro Santos-MorenoBiomab - Centro de Artritis Reumatoide, Bogotá, Colombia.ORCID 0000-0001-7802-0317
Lene TerslevCopenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet Glostrup, Copenhagen, Denmark.ORCID 0000-0001-8193-9471
Maria Antonietta D'AgostinoDivision of Rheumatology and Clinical Immunology, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy.
Ingrid MöllerInstituto Poal de Reumatologia, Barcelona, Spain.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo provide a comprehensive description of a standardised, landmark-based ultrasound (US) technique for evaluating the lateral costotransverse (LCTL), supraspinous (SSL) and iliolumbar (ILL) ligaments of the thoracolumbar spine and to assess its reliability, feasibility and its potential applicability in spondyloarthritis (SpA).

methodsLCTL, SSL and ILL were examined using US in specimens, followed by dissection to confirm structure location and validate US findings using a standardised anatomic-based and sonoanatomic-based landmark approach. The US technique was subsequently applied in 20 healthy controls (HC), in whom feasibility and inter-rater and intra-rater reliability among four operators with different expertise were assessed. Ligament visualisation was scored as: 0, not visualised; 1, incompletely visualised; 2, perfectly visualised. The technique was tested in three patients with SpA to evaluate its applicability.

resultsAnatomical study confirmed location and landmarks for all three ligaments. 120 ligaments were assessed in two rounds in HC. Visualisation scores ranged from 1 to 2 in 100% LCTL, 99.1% SSL and 85.9% ILL, with score 2 obtained in 69.6% of 960 assessments. Mean examination time decreased from 12'17″ to 10'56″ between rounds, with no significant differences between operators. Intra-rater and inter-rater agreement ranged from moderate to high. In patients with SpA, US detected both inflammatory and structural lesions in the three ligament entheses.

conclusionThe proposed standardised US approach allows reliable assessment of LCTL, SSL and ILL. This technique provides a robust and reproducible method for evaluating the ligaments of the thoracolumbar spine and opens a new approach to the US assessment of patients with spinal inflammatory diseases, including SpA.

Indexed as

LigamentsSpineSpondylarthritisAdultFemaleHumansLumbar VertebraeMaleMiddle AgedReproducibility of ResultsUltrasonographyArthritis, PsoriaticAxial SpondyloarthritisLigamentsStandardizationUltrasonography

Identifiers

PMID42114895
PMCPMC13182462

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.