ReviewMatrix biology : journal of the International Society for Matrix Biology2026
Testican-2 (SPOCK2): A multifunctional matricellular regulator.
Review in Matrix biology : journal of the International Society for Matrix Biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
4 authors.
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Abstract
Testican-2 (SPOCK2) is a secreted, extracellular matrix-associated proteoglycan that modulates cell-matrix interactions, extracellular proteolysis, and tissue-specific signaling across multiple organs. Beyond its initial characterization in the central nervous system, subsequent studies have established roles in the lung, pancreas, bone, and kidney, where testican-2 regulates tissue remodeling and extracellular matrix dynamics under both physiological and disease conditions. Mechanistic, genetic, and proteomic studies highlight its dual role as a biomarker and functional modulator, with kidney disease emerging as a clinically relevant context. However, upstream regulators, cell-type-specific functions, context-dependent effects, and the structural basis underlying its domain-specific interactions remain to be fully defined. This review synthesizes current evidence on testican-2 biology across tissues and disease settings, highlighting emerging themes and unresolved questions. A clearer understanding of its regulation and function will help refine its value as a biomarker and potential therapeutic target.
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