Evidence map›Paper›PMID 42114269›Full record

ReviewFEMS microbiology reviews2026

Bacterial quorum-sensing systems in cell-cell communication.

Kai-Zhong Xu, Annadurai Vinothkanna, DanDan Wang, Hongyan Jiang, Zhenbo Xu, Ai-Qun Jia

Abstract readReview
In one paragraph

Review in FEMS microbiology reviews, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Polysaccharide based biomaterials for advanced wound healing applications.Frontiers in cellular and infection microbiology · 2026
    Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Kai-Zhong XuCollege of Food Engineering, Zhangzhou Institute of Technology, Zhangzhou363000, China.
Annadurai VinothkannaHainan General Hospital, Hainan Affiliated Hospital of Hainan Medical University, Haikou570311, China.
DanDan WangHainan General Hospital, Hainan Affiliated Hospital of Hainan Medical University, Haikou570311, China.
Hongyan JiangHainan General Hospital, Hainan Affiliated Hospital of Hainan Medical University, Haikou570311, China.
Zhenbo XuDepartment of Laboratory Medicine, the Second Affiliated Hospital of Shantou University Medical College, Shantou515041, China.ORCID 0000-0003-2865-2441
Ai-Qun JiaHainan General Hospital, Hainan Affiliated Hospital of Hainan Medical University, Haikou570311, China.

Funding

National Natural Science Foundation of China 82160664Natural Science Foundation of Hainan Province 221CXTD434Natural Science Foundation of Zhangzhou Joint Research Program ZZ2025LH28
6 · The paper itself

Abstract

Antimicrobial resistance (AMR) and the emergence of multidrug-resistant pathogens necessitate holistic care. Novel antimicrobial drug discovery involves an in-depth assessment of quorum sensing (QS) signaling and cell-cell communication. Bacteria regulate their metabolism to cope with complex host-environmental changes through QS signaling. Previous studies suggest that the social behaviors of bacteria include biofilm formation, virulence, and drug resistance mediated by QS. Over several decades, autoinducer receptors, signaling pathways, and the regulatory networks that control gene expression have corroborated QS signaling molecules. Multiple QS systems and chemical structural diversity signaling molecules have been sporadically reported, but there is no comprehensive review of these findings. This review systematically and comprehensively summarizes the paper, addressing bacterial QS-based cell-cell communication and the potential mechanisms of QS systems in bacterial drug resistance. Furthermore, a status quo update has been established for novel QS systems in the realms of pathogenicity, polymicrobial interactions, and/or AMR patterns. Nevertheless, the applications of QS systems would invoke newer incorporations for futuristic research values. Thus, the complexity and evolutionary insights of QS systems, quorum-sensing signaling molecules, and regulatory mechanisms need a "cloud" based repurposing for the design of novel agents in AMR and communication.

Indexed as

BacteriaBacterial Physiological PhenomenaCell CommunicationQuorum SensingAnti-Bacterial AgentsBiofilmsDrug Resistance, BacterialGene Expression Regulation, BacterialSignal TransductionAnti-Bacterial Agentsantimicrobial drug resistancebacteriacell–cell communicationquorum-sensing systemssignaling molecules

Identifiers

PMID42114269
PMCPMC13220807

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.