ArticleRheumatology (Oxford, England)2026
Predictive correlates of arthritis and joint damage in systemic lupus erythematosus: a multinational prospective cohort study.
Luigi Zolio, Yanjie Hao, Rangi Kandane-Rathnayake, Worawit Louthrenoo, Yi-Hsing Chen, Jiacai Cho, Aisha Lateef, Laniyati Hamijoyo, Shue Fen Luo, Yeong-Jian Jan Wu and 29 more
Abstract readMulticenter Study
In one paragraphArticle in Rheumatology (Oxford, England), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 · Who and what moneyAuthors and funding
39 authors.
Luigi ZolioDepartment of Medicine, University of Melbourne at St Vincent's Hospital, Fitzroy, VIC, Australia.ORCID 0000-0003-4645-3411 Yanjie HaoDepartment of Medicine, University of Melbourne at St Vincent's Hospital, Fitzroy, VIC, Australia.ORCID 0000-0001-8715-259X Rangi Kandane-RathnayakeCentre for Inflammatory Diseases, School of Clinical Sciences, Monash University, Clayton, VIC, Australia.ORCID 0000-0001-5397-1482 Worawit LouthrenooDepartment of Internal Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.ORCID 0000-0003-3105-6122 Yi-Hsing ChenDivision of Allergy, Immunology and Rheumatology, Taichung Veterans General Hospital, Taichung, Taiwan, Republic of China.ORCID 0000-0002-8135-9554 Laniyati HamijoyoDepartment of Internal Medicine, Faculty of Medicine, Padjadjaran University, Bandung, Indonesia.ORCID 0000-0002-1310-674X Shue Fen LuoDepartment of Rheumatology, Allergy and Immunology, Chang Gung Memorial Hospital, Taipei, Taiwan, Republic of China.ORCID 0000-0001-6559-4434 Yeong-Jian Jan WuDepartment of Rheumatology, Allergy and Immunology, Chang Gung Memorial Hospital, Taipei, Taiwan, Republic of China.ORCID 0000-0002-5444-4729 Zhanguo LiDepartment of Rheumatology and Immunology, People's Hospital, Peking University Health Science Center, Beijing, China.ORCID 0000-0002-2590-6242 Sargunan SockalingamDepartment of Medicine, Universiti Malaya Medical Centre, Kuala Lumpur, Malaysia.ORCID 0000-0002-7266-9526 Yasuhiro KatsumataDivision of Rheumatology, Department of Internal Medicine, Tokyo Women's Medical University School of Medicine, Tokyo, Japan.ORCID 0000-0003-1654-0119 Masayoshi HarigaiDivision of Rheumatology, Department of Internal Medicine, Tokyo Women's Medical University School of Medicine, Tokyo, Japan.ORCID 0000-0002-6418-2603 Zhuoli ZhangRheumatology and Immunology Department, Peking University First Hospital, Beijing, China.ORCID 0000-0001-7219-9141 Madelynn ChanDepartment of Rheumatology, Allergy & Immunology, Tan Tock Seng Hospital, Singapore, Singapore.ORCID 0000-0002-8102-7664 Jun KikuchiDivision of Rheumatology, Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan.ORCID 0000-0003-3231-8841 Tsutomu TakeuchiDivision of Rheumatology, Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan.ORCID 0000-0003-1111-8218 Sang-Cheol BaeHanyang University Hospital for Rheumatic Diseases, Hanyang University Institute for Rheumatology Research and Hanyang Institute of Bioscience and Biotechnology, Seoul, South Korea.ORCID 0000-0003-4658-1093 Kristine Pek Ling NgDepartment of Rheumatology, North Shore Hospital, Health New Zealand Waitemata, Auckland, New Zealand.ORCID 0009-0006-6225-2715 Yih Jia PohDepartment of Rheumatology and Immunology, Singapore General Hospital, Singapore.
Bmdb BasnayakeDepartment of Nephrology, Teaching Hospital Kandy, Kandy, Sri Lanka.
Nicola TugnetDepartment of Rheumatology, Greenlane Clinical Centre, Health New Zealand Auckland, Te Whatu Ora, Auckland, New Zealand.
Mark SapsfordDepartment of Rheumatology, Middlemore Hospital, Health New Zealand Counties Manukau, Te Whatu Ora, Auckland, New Zealand.ORCID 0000-0002-4376-4241 Yoshiya TanakaThe First Department of Internal Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan.ORCID 0000-0002-0807-7139 Vera GolderCentre for Inflammatory Diseases, School of Clinical Sciences, Monash University, Clayton, VIC, Australia.ORCID 0000-0001-5691-4344 Alberta HoiCentre for Inflammatory Diseases, School of Clinical Sciences, Monash University, Clayton, VIC, Australia.ORCID 0000-0002-9416-7383 Eric MorandCentre for Inflammatory Diseases, School of Clinical Sciences, Monash University, Clayton, VIC, Australia.ORCID 0000-0002-9507-3338 Shereen OonDepartment of Medicine, University of Melbourne at St Vincent's Hospital, Fitzroy, VIC, Australia.ORCID 0000-0002-6822-5711 Mandana NikpourDepartment of Medicine, University of Melbourne at St Vincent's Hospital, Fitzroy, VIC, Australia.ORCID 0000-0002-6585-5611 Funding
AstraZenecaBristol Myers SquibbEli Lilly, Janssen, Merck Serono
6 · The paper itselfAbstract
objectivesTo determine the prevalence and predictive correlates of arthritis and joint damage in systemic lupus erythematosus (SLE) patients in the Asia-Pacific Lupus Collaboration (APLC) cohort, and to determine their impact on health-related quality of life (HRQoL).
methodsSLE patient data (2013-2020) were collected from the prospective multinational APLC cohort. We defined arthritis according to the SLE Disease Assessment Index (SLEDAI-2K) definition of persistent arthritis as arthritis in ≥2 consecutive visits, and joint damage according to the Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index (SDI) definition (deforming or erosive arthritis). HRQoL was measured by Short Form Survey (SF36). Descriptive statistics, univariable and multivariable Cox hazard models, and Kaplan-Meier analyses were performed.
resultsDuring median 2.5 (1.0-5.1) years of follow-up, 803/4106 (19.6%) patients had arthritis at least once, and 18/3383 (0.53%) accrued joint damage. Patients with arthritis were more likely to be female, Caucasian, current smokers at enrolment, and less like to have tertiary education; they also had higher overall disease activity, and lower physical and mental HRQoL. Kaplan-Meier analysis demonstrated that joint damage was more likely in patients with arthritis. Persistent arthritis and longer follow-up were risk factors for joint damage accrual; being from high-income countries was protective. Patients with joint damage also had worse physical HRQoL.
conclusionArthritis in the APLC cohort was infrequent compared with other cohorts and was associated with smoking, higher overall disease activity, and damage accrual across multiple domains. Presence of arthritis significantly impacted physical and mental HRQoL. Joint damage was strongly predicted by persistent arthritis.
Indexed as
ArthritisLupus Erythematosus, SystemicQuality of LifeAdultFemaleHumansMaleMiddle AgedPrevalenceProspective StudiesSeverity of Illness Indexarthritisepidemiologyjoint damagequality of lifesystemic lupus erythematosus
Identifiers
PMID42114134
PMCPMC13268536
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