ArticleJornal brasileiro de nefrologia
Sex-specific differences in serum phosphate persist in patients with CKD.
Article in Jornal brasileiro de nefrologia. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
introductionPhosphate plays a critical role in numerous metabolic processes, and sex-specific differences have been identified in its concentrations in the general population. However, such differences have not been investigated in the context of CKD, in which additional factors may exert a more pronounced impact on these levels.
methodsThis retrospective study was conducted in an outpatient nephrology clinic and included data from 632 patients with CKD stages 1-5.
resultsSerum phosphate was negatively associated with age (r = -0.08; p = 0.04) and estimated glomerular filtration rate (eGFR) (r = -0.23; p < 0.001). Women had significantly higher serum phosphate levels than men (3.6 mg/dL vs. 3.3 mg/dL; p = 0.01), an association confirmed in multivariate analysis. No significant sex differences were observed in serum calcium, parathyroid hormone (PTH), 25-hydroxyvitamin D, or the use of vitamin D supplements, calcium salts, or calcitriol.
conclusionEven in the presence of CKD, women have higher serum phosphate (P) levels than men. This sex difference should be considered in the management of CKD-mineral and bone disorder (CKD-MBD).
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