Evidence map›Paper›PMID 42113975›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2026

Deep-learning endomicroscope with large field-of-view and depth-of-field for real-time in vivo imaging of epithelial cancer hallmarks.

Huayu Hou, Jimin Wu, Jinyun Liu, Vivek Boominathan, Argaja Shende, Karthik Goli, Jennifer Carns, Richard A Schwarz, Ann M Gillenwater, Preetha Ramalingam and 6 more

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors.

Huayu Hou *Department of Bioengineering, Rice University, Houston, TX 77005.ORCID 0000-0003-3996-0327
Jimin Wu *Department of Bioengineering, Rice University, Houston, TX 77005.ORCID 0000-0001-6383-9020
Jinyun LiuDepartment of Bioengineering, Rice University, Houston, TX 77005.
Vivek BoominathanDepartment of Electrical and Computer Engineering, Rice University, Houston, TX 77005.ORCID 0000-0003-4875-3135
Argaja ShendeDepartment of Bioengineering, Rice University, Houston, TX 77005.
Karthik GoliDepartment of Bioengineering, Rice University, Houston, TX 77005.
Jennifer CarnsDepartment of Bioengineering, Rice University, Houston, TX 77005.
Richard A SchwarzDepartment of Bioengineering, Rice University, Houston, TX 77005.
Ann M GillenwaterDepartment of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX 77030.
Preetha RamalingamDepartment of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030.
Mila P SalcedoDepartment of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030.
Kathleen M SchmelerDepartment of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030.
Tomasz S TkaczykDepartment of Bioengineering, Rice University, Houston, TX 77005.
Jacob T RobinsonDepartment of Bioengineering, Rice University, Houston, TX 77005.ORCID 0000-0002-3509-3054
Ashok VeeraraghavanDepartment of Electrical and Computer Engineering, Rice University, Houston, TX 77005.ORCID 0000-0001-5043-7460
Rebecca R Richards-KortumDepartment of Bioengineering, Rice University, Houston, TX 77005.ORCID 0000-0003-2347-9467

Funding

Tumor Evolution and Metastasis ProgramP30CA016672 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Scott Kopetz · 1985 to 2026
$290.8M
The AVANÇO Research Consortium: A Mozambique/Brazil/Texas Alliance to advance novel and affordable technologies for the prevention and diagnosis of cervical cancer in women living with HIVU54CA277843 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI regis kreitchmann · 2023 to 2026
$5.3M
Deep learning microscope for slide-free and digital histologyR01DE032051 · NIDCR · RICE UNIVERSITY · PI Ann M Gillenwater, Rebecca R. Richards-Kortum · 2022 to 2026
$3.5M
Precision Optical Guidance for Oral Biopsy Based on Next-Generation Hallmarks of CancerR01DE029590 · NIDCR · RICE UNIVERSITY · PI GILLENWATER, ANN M, RICHARDS-KORTUM, REBECCA R. · 2020 to 2024
$3.2M
DOD | Defense Advanced Research Projects Agency (ARPA) D20AC00002HHS | NIH | National Cancer Institute (NCI) P30CA016672HHS | NIH | National Cancer Institute (NCI) U54CA277843HHS | NIH | National Institute of Dental and Craniofacial Research (NIDR) R01DE029590HHS | NIH | National Institute of Dental and Craniofacial Research (NIDR) R01DE032051NCI NIH HHS P30 CA016672NCI NIH HHS U54 CA277843NIDCR NIH HHS R01 DE029590NIDCR NIH HHS R01 DE032051NSF (NSF) IIS-1652633NSF (NSF) IIS-1730574
6 · The paper itself

Abstract

In vivo microscopy (IVM) has shown great promise to improve early detection of epithelial precancer, but it suffers from fundamental trade-offs that limit the resolution, field-of-view (FOV) and depth-of-field (DOF). Here, we present PrecisionView, a compact, deep learning-enabled endomicroscope that breaks these constraints and achieves 20 mm

Indexed as

Deep LearningNeoplasms, Glandular and EpithelialEpithelial CellsFemaleHumansImage Processing, Computer-AssistedPrecancerous Conditionsdeep learningendomicroscopyextended depth-of-fieldin vivo imaginglarge field-of-view

Identifiers

PMID42113975
PMCPMC13187819

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.