ArticlePloS one2026
Translating research into action: Policy recommendations for strengthening antiretroviral therapy adherence in Ghana based on empirical evidence.
Article in PloS one, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Despite significant advances in antiretroviral therapy (ART) accessibility in Ghana, suboptimal adherence remains a critical challenge undermining treatment effectiveness. This article presents evidence-based policy hypotheses derived from a comprehensive mixed-methods investigation of ART adherence determinants among 2,000 people living with HIV in Ghana#39;s Ashanti Region. We hypothesize that multisectoral policy interventions addressing economic barriers, healthcare system deficiencies, and socio-cultural obstacles will significantly improve adherence rates beyond conventional clinical approaches. Specifically, we propose that: (1) integrated transportation support systems will substantially reduce missed appointments; (2) decentralized medication distribution networks incorporating community-based refill options will improve medication access; (3) restructured clinic operations emphasizing reduced waiting times and privacy protection will enhance engagement; and (4) formalized income protection and nutritional support policies will address critical economic barriers to consistent treatment. These policy hypotheses extend beyond individual-focused interventions to address structural determinants of adherence, offering testable frameworks for evidence-based policy development in resource-limited settings.
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